Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits
The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from <em>C. sativum</em> L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the ma...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/7/8439 |
| _version_ | 1824007002435616768 |
|---|---|
| author | Erika H. S. Brito Carolina S. P. Cavalcante Marcos F. G. Rocha Débora S. C. M. Castelo-Branco Manoel A. S. Neto Edy S. Brito Bruna V. Soares Selene M. Morais Raquel Oliveira dos Santos Fontenelle Christiana M. C. Pereira Nadja S. Vila-Nova Vanessa A. Queiroz |
| author_facet | Erika H. S. Brito Carolina S. P. Cavalcante Marcos F. G. Rocha Débora S. C. M. Castelo-Branco Manoel A. S. Neto Edy S. Brito Bruna V. Soares Selene M. Morais Raquel Oliveira dos Santos Fontenelle Christiana M. C. Pereira Nadja S. Vila-Nova Vanessa A. Queiroz |
| author_sort | Erika H. S. Brito |
| collection | DOAJ |
| description | The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from <em>C. sativum</em> L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC<sub>50</sub> value of 23 µg/mL in the <em>Artemia salina</em> lethality test. The antifungal activity was evaluated against <em>Microsporum canis</em> and <em>Candida</em> spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for <em>M. canis</em> and <em>Candida</em> spp. respectively. The MICs and MFCs for <em>M. canis</em> strains ranged from 78 to 620 and 150 to 1,250 µg/mL, and the MICs and MFCs for <em>Candida</em> spp strains ranged from 310 to 620 and 620 to 1,250 µg/mL, respectively. <em>C. sativum</em> essential oil is active<em> in vitro</em> against <em>M. canis </em>and<em> Candida</em> spp. demonstrating good antifungal activity. |
| first_indexed | 2024-12-18T20:35:12Z |
| format | Article |
| id | doaj.art-5eb1c0c26de74220b7d0dd16983281c7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T20:35:12Z |
| publishDate | 2012-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5eb1c0c26de74220b7d0dd16983281c72022-12-21T20:53:55ZengMDPI AGMolecules1420-30492012-07-011778439844810.3390/molecules17078439Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. FruitsErika H. S. BritoCarolina S. P. CavalcanteMarcos F. G. RochaDébora S. C. M. Castelo-BrancoManoel A. S. NetoEdy S. BritoBruna V. SoaresSelene M. MoraisRaquel Oliveira dos Santos FontenelleChristiana M. C. PereiraNadja S. Vila-NovaVanessa A. QueirozThe aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from <em>C. sativum</em> L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC<sub>50</sub> value of 23 µg/mL in the <em>Artemia salina</em> lethality test. The antifungal activity was evaluated against <em>Microsporum canis</em> and <em>Candida</em> spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for <em>M. canis</em> and <em>Candida</em> spp. respectively. The MICs and MFCs for <em>M. canis</em> strains ranged from 78 to 620 and 150 to 1,250 µg/mL, and the MICs and MFCs for <em>Candida</em> spp strains ranged from 310 to 620 and 620 to 1,250 µg/mL, respectively. <em>C. sativum</em> essential oil is active<em> in vitro</em> against <em>M. canis </em>and<em> Candida</em> spp. demonstrating good antifungal activity.http://www.mdpi.com/1420-3049/17/7/8439<em>Coriandrum sativum</em>essential oil<em>Microsporum canis</em><em>Candida</em> spp.<em>Artemia salina</em>linalool |
| spellingShingle | Erika H. S. Brito Carolina S. P. Cavalcante Marcos F. G. Rocha Débora S. C. M. Castelo-Branco Manoel A. S. Neto Edy S. Brito Bruna V. Soares Selene M. Morais Raquel Oliveira dos Santos Fontenelle Christiana M. C. Pereira Nadja S. Vila-Nova Vanessa A. Queiroz Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits Molecules <em>Coriandrum sativum</em> essential oil <em>Microsporum canis</em> <em>Candida</em> spp. <em>Artemia salina</em> linalool |
| title | Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits |
| title_full | Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits |
| title_fullStr | Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits |
| title_full_unstemmed | Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits |
| title_short | Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of <em>Coriandrum sativum</em> L. Fruits |
| title_sort | antifungal activity toxicity and chemical composition of the essential oil of lt em gt coriandrum sativum lt em gt l fruits |
| topic | <em>Coriandrum sativum</em> essential oil <em>Microsporum canis</em> <em>Candida</em> spp. <em>Artemia salina</em> linalool |
| url | http://www.mdpi.com/1420-3049/17/7/8439 |
| work_keys_str_mv | AT erikahsbrito antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT carolinaspcavalcante antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT marcosfgrocha antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT deborascmcastelobranco antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT manoelasneto antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT edysbrito antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT brunavsoares antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT selenemmorais antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT raqueloliveiradossantosfontenelle antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT christianamcpereira antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT nadjasvilanova antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits AT vanessaaqueiroz antifungalactivitytoxicityandchemicalcompositionoftheessentialoilofltemgtcoriandrumsativumltemgtlfruits |