Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS‐STING Signaling
Abstract To evade immune surveillance, tumor cells express ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) on the surface of their membrane, which degrades extracellular cyclic GMP‐AMP (cGAMP), thereby inhibiting the cyclic GMP‐AMP synthase (cGAS) stimulator of interferon gene (STING) DNA...
| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Wiley
2024-05-01
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| Collection: | Advanced Science |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1002/advs.202308131 |