A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke
Background: Role of Serum Lipids, Lipoproteins and Lipoprotein related variables in the prediction of Stroke is less clear. Abnormalities in plasma Lipoproteins are the most firmly established and best understood risk factors for Atherosclerosis and they are probable risk factors for Ischaemic s...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/3123/9%20-%205269_PF1(M)_E(C)_F(T)_F1(V)_F1(T)_PF1(PUH)_PFA(H)_1.pdf |
| _version_ | 1818110845990731776 |
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| author | Shilpasree AS Savitri Sahukar Jayaprakash Murthy Kiran Kumar |
| author_facet | Shilpasree AS Savitri Sahukar Jayaprakash Murthy Kiran Kumar |
| author_sort | Shilpasree AS |
| collection | DOAJ |
| description | Background: Role of Serum Lipids, Lipoproteins and Lipoprotein
related variables in the prediction of Stroke is less clear. Abnormalities
in plasma Lipoproteins are the most firmly established and best
understood risk factors for Atherosclerosis and they are probable risk
factors for Ischaemic stroke, largely by their link to Atherosclerosis.
Apo B reflects the concentration of potentially atherogenic particles
(LDL), and Apo A1 reflects the corresponding concentration of antiatherogenic particles (HDL), represent additional lipoprotein related
variables that may indicate the vascular risk.
Aim: To study serum concentration of Apolipoprotein A1,
Apolipoprotein B, Apo B/Apo A1 ratio and Lipid profile in Stroke
Cases and to compare with healthy controls.
Design: . A total number of 100 subjects within 30 – 70 years
were considered for the study. 50 subjects with Stroke (both
clinically as well as Computed tomographically proven cases)
and 50 age and sex matched healthy individuals were taken for
the study
Material and Methods: Total cholesterol, HDL cholesterol
and Triglycerides are estimated by Enzymatic method
using Semiautoanalyser. LDL cholesterol is estimated by
Friedewald formula. Apo B and Apo A1 are estimated by
Immunoturbidimetric method using Semiautoanalyser.
Statistical Analysis: Student ‘t’ test was used to compare the
data between cases and controls. Diagnostic validity tests were
conducted to assess the Diagnostic efficiency of Apo A1, Apo B
and Apo B/Apo A1 ratio.
Results: Total cholesterol, LDL cholesterol and Triglycerides
are significantly increased in Cases compared to Controls. HDL
– cholesterol is significantly decreased in Cases compared
to Controls. Apo B and Apo B/Apo A1 ratio are significantly
increased and Apo A1 is significantly decreased in Cases
compared to Controls. Diagnostic validity tests showed that,
Apo B , Apo A1 and Apo B /Apo A1 ratio have highest Sensitivity,
Specificity and Diagnostic efficiency.
Conclusion: Apo B , Apo A1 and Apo B / Apo A1 ratio can be
used as predictors of stroke along with traditional lipid profile
components. |
| first_indexed | 2024-12-11T02:53:38Z |
| format | Article |
| id | doaj.art-5eb3fbae7a504aad941cf560e2fc3306 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T02:53:38Z |
| publishDate | 2013-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5eb3fbae7a504aad941cf560e2fc33062022-12-22T01:23:13ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-07-01771303130610.7860/JCDR/2013/5269.3123A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in StrokeShilpasree AS0Savitri Sahukar1Jayaprakash Murthy2Kiran Kumar3Assistant Professor, Department of Biochemistry, Santosh Medical College, Ghaziabad, UP – 201206, India.Professor, Department of Biochemistry, JJM Medical College, Davangere – 577005, India.Professor and Head, Department of Biochemistry, JJM Medical College, Davangere – 577005, India.Reader, Department of Oral Pathology, ITS – CDSR Muradnagar, Ghaziabad, UP – 201206, India.Background: Role of Serum Lipids, Lipoproteins and Lipoprotein related variables in the prediction of Stroke is less clear. Abnormalities in plasma Lipoproteins are the most firmly established and best understood risk factors for Atherosclerosis and they are probable risk factors for Ischaemic stroke, largely by their link to Atherosclerosis. Apo B reflects the concentration of potentially atherogenic particles (LDL), and Apo A1 reflects the corresponding concentration of antiatherogenic particles (HDL), represent additional lipoprotein related variables that may indicate the vascular risk. Aim: To study serum concentration of Apolipoprotein A1, Apolipoprotein B, Apo B/Apo A1 ratio and Lipid profile in Stroke Cases and to compare with healthy controls. Design: . A total number of 100 subjects within 30 – 70 years were considered for the study. 50 subjects with Stroke (both clinically as well as Computed tomographically proven cases) and 50 age and sex matched healthy individuals were taken for the study Material and Methods: Total cholesterol, HDL cholesterol and Triglycerides are estimated by Enzymatic method using Semiautoanalyser. LDL cholesterol is estimated by Friedewald formula. Apo B and Apo A1 are estimated by Immunoturbidimetric method using Semiautoanalyser. Statistical Analysis: Student ‘t’ test was used to compare the data between cases and controls. Diagnostic validity tests were conducted to assess the Diagnostic efficiency of Apo A1, Apo B and Apo B/Apo A1 ratio. Results: Total cholesterol, LDL cholesterol and Triglycerides are significantly increased in Cases compared to Controls. HDL – cholesterol is significantly decreased in Cases compared to Controls. Apo B and Apo B/Apo A1 ratio are significantly increased and Apo A1 is significantly decreased in Cases compared to Controls. Diagnostic validity tests showed that, Apo B , Apo A1 and Apo B /Apo A1 ratio have highest Sensitivity, Specificity and Diagnostic efficiency. Conclusion: Apo B , Apo A1 and Apo B / Apo A1 ratio can be used as predictors of stroke along with traditional lipid profile components.https://jcdr.net/articles/PDF/3123/9%20-%205269_PF1(M)_E(C)_F(T)_F1(V)_F1(T)_PF1(PUH)_PFA(H)_1.pdfapolipoprotein a1apolipoprotein blipid profilestroke |
| spellingShingle | Shilpasree AS Savitri Sahukar Jayaprakash Murthy Kiran Kumar A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke Journal of Clinical and Diagnostic Research apolipoprotein a1 apolipoprotein b lipid profile stroke |
| title | A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke |
| title_full | A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke |
| title_fullStr | A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke |
| title_full_unstemmed | A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke |
| title_short | A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke |
| title_sort | study of serum apolipoprotein a1 apolipoprotein b and lipid profile in stroke |
| topic | apolipoprotein a1 apolipoprotein b lipid profile stroke |
| url | https://jcdr.net/articles/PDF/3123/9%20-%205269_PF1(M)_E(C)_F(T)_F1(V)_F1(T)_PF1(PUH)_PFA(H)_1.pdf |
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