Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview
Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating from B, T, or NK lymphocytes. They represent approximately 4–5% of new cancer cases and are classified according to the revised WHO system based on cell lineage, morphology, immunophenotype, and gen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.mdpi.com/2038-8330/16/1/17 |
| _version_ | 1797240816208445440 |
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| author | Antonella Argentiero Alessandro Andriano Donatello Marziliano Vanessa Desantis |
| author_facet | Antonella Argentiero Alessandro Andriano Donatello Marziliano Vanessa Desantis |
| author_sort | Antonella Argentiero |
| collection | DOAJ |
| description | Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating from B, T, or NK lymphocytes. They represent approximately 4–5% of new cancer cases and are classified according to the revised WHO system based on cell lineage, morphology, immunophenotype, and genetics. Diagnosis requires adequate biopsy material, though integrated approaches are used for leukemic presentations. Molecular profiling is improving classification and identifying prognostic markers. Indolent NHLs, such as follicular lymphoma and marginal zone lymphoma, typically pursue a non-aggressive clinical course with long survival. Aggressive diffuse large B-cell lymphoma (DLBCL) is the most common subtype. Recent studies have elucidated pathogenic mechanisms like MYC translocations and BCR pathway mutations. “Double hit” lymphomas with MYC and BCL2/BCL6 alterations confer a poor prognosis. Treatment approaches are evolving, with chemoimmunotherapy remaining standard for many indolent cases while intensified regimens and targeted agents show promise for refractory or high-risk aggressive disease. Continued elucidation of the genetic and microenvironmental underpinnings of lymphomagenesis is critical for developing personalized therapeutic strategies. |
| first_indexed | 2024-04-24T18:13:26Z |
| format | Article |
| id | doaj.art-5eb788933dbd474fb6ef7b84228d6ccc |
| institution | Directory Open Access Journal |
| issn | 2038-8330 |
| language | English |
| last_indexed | 2024-04-24T18:13:26Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-5eb788933dbd474fb6ef7b84228d6ccc2024-03-27T13:44:00ZengMDPI AGHematology Reports2038-83302024-03-0116116417810.3390/hematolrep16010017Navigating Lymphomas through BCR Signaling and Double-Hit Insights: OverviewAntonella Argentiero0Alessandro Andriano1Donatello Marziliano2Vanessa Desantis3Istituto Tumori “Giovanni Paolo II”, Istituto di Ricovero e Cura a Carattere Scientifico, 70124 Bari, ItalyPharmacology Section, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro Medical School, 70124 Bari, ItalyUnit of Internal Medicine “G. Baccelli”, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro Medical School, 70124 Bari, ItalyPharmacology Section, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro Medical School, 70124 Bari, ItalyNon-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating from B, T, or NK lymphocytes. They represent approximately 4–5% of new cancer cases and are classified according to the revised WHO system based on cell lineage, morphology, immunophenotype, and genetics. Diagnosis requires adequate biopsy material, though integrated approaches are used for leukemic presentations. Molecular profiling is improving classification and identifying prognostic markers. Indolent NHLs, such as follicular lymphoma and marginal zone lymphoma, typically pursue a non-aggressive clinical course with long survival. Aggressive diffuse large B-cell lymphoma (DLBCL) is the most common subtype. Recent studies have elucidated pathogenic mechanisms like MYC translocations and BCR pathway mutations. “Double hit” lymphomas with MYC and BCL2/BCL6 alterations confer a poor prognosis. Treatment approaches are evolving, with chemoimmunotherapy remaining standard for many indolent cases while intensified regimens and targeted agents show promise for refractory or high-risk aggressive disease. Continued elucidation of the genetic and microenvironmental underpinnings of lymphomagenesis is critical for developing personalized therapeutic strategies.https://www.mdpi.com/2038-8330/16/1/17non-Hodgkin’s lymphomasBCR signalingdouble-hit lymphoma |
| spellingShingle | Antonella Argentiero Alessandro Andriano Donatello Marziliano Vanessa Desantis Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview Hematology Reports non-Hodgkin’s lymphomas BCR signaling double-hit lymphoma |
| title | Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview |
| title_full | Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview |
| title_fullStr | Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview |
| title_full_unstemmed | Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview |
| title_short | Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview |
| title_sort | navigating lymphomas through bcr signaling and double hit insights overview |
| topic | non-Hodgkin’s lymphomas BCR signaling double-hit lymphoma |
| url | https://www.mdpi.com/2038-8330/16/1/17 |
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