Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33#
Four new chromone derivatives, phomopsichins A–D (1–4), along with a known compound, phomoxanthone A (5), were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp. 33#. Their structures were elucidated based on comprehensive spectroscopic analysis coupled with single-c...
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| Format: | Article |
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MDPI AG
2016-11-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/11/215 |
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| author | Meixiang Huang Jing Li Lan Liu Sheng Yin Jun Wang Yongcheng Lin |
| author_facet | Meixiang Huang Jing Li Lan Liu Sheng Yin Jun Wang Yongcheng Lin |
| author_sort | Meixiang Huang |
| collection | DOAJ |
| description | Four new chromone derivatives, phomopsichins A–D (1–4), along with a known compound, phomoxanthone A (5), were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp. 33#. Their structures were elucidated based on comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction or theoretical calculations of electronic circular dichroism (ECD). They feature a tricyclic framework, in which a dihydropyran ring is fused with the chromone ring. Compounds 1–5 showed weak inhibitory activities on acetylcholinesterase as well as α-glucosidase, weak radical scavenging effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as OH, and weak antimicrobial activities. Compounds 1–4 showed no cytotoxic activity against MDA-MB-435 breast cancer cells. Their other bioactivities are worthy of further study, considering their unique molecular structures. |
| first_indexed | 2024-04-14T01:04:13Z |
| format | Article |
| id | doaj.art-5ebc583690564125b7a116b9e74992d4 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:04:13Z |
| publishDate | 2016-11-01 |
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| series | Marine Drugs |
| spelling | doaj.art-5ebc583690564125b7a116b9e74992d42022-12-22T02:21:18ZengMDPI AGMarine Drugs1660-33972016-11-01141121510.3390/md14110215md14110215Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33#Meixiang Huang0Jing Li1Lan Liu2Sheng Yin3Jun Wang4Yongcheng Lin5School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaKey Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, ChinaFour new chromone derivatives, phomopsichins A–D (1–4), along with a known compound, phomoxanthone A (5), were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp. 33#. Their structures were elucidated based on comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction or theoretical calculations of electronic circular dichroism (ECD). They feature a tricyclic framework, in which a dihydropyran ring is fused with the chromone ring. Compounds 1–5 showed weak inhibitory activities on acetylcholinesterase as well as α-glucosidase, weak radical scavenging effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as OH, and weak antimicrobial activities. Compounds 1–4 showed no cytotoxic activity against MDA-MB-435 breast cancer cells. Their other bioactivities are worthy of further study, considering their unique molecular structures.http://www.mdpi.com/1660-3397/14/11/215mangrove endophytic fungiPhomopsis sp.secondary metaboliteschromone derivatives |
| spellingShingle | Meixiang Huang Jing Li Lan Liu Sheng Yin Jun Wang Yongcheng Lin Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33# Marine Drugs mangrove endophytic fungi Phomopsis sp. secondary metabolites chromone derivatives |
| title | Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33# |
| title_full | Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33# |
| title_fullStr | Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33# |
| title_full_unstemmed | Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33# |
| title_short | Phomopsichin A–D; Four New Chromone Derivatives from Mangrove Endophytic Fungus Phomopsis sp. 33# |
| title_sort | phomopsichin a d four new chromone derivatives from mangrove endophytic fungus phomopsis sp 33 |
| topic | mangrove endophytic fungi Phomopsis sp. secondary metabolites chromone derivatives |
| url | http://www.mdpi.com/1660-3397/14/11/215 |
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