Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty
Frailty is characterized by reduced physiological reserves across multiple systems. In patients with frailty, oncological surgery has been associated with a high rate of postoperative complications and worse overall survival. Further, given that cancer and frailty can co-exist in the same patient, c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/15/5041 |
| _version_ | 1797586519642341376 |
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| author | Hiromichi Maeda Michiko Takahashi Satoru Seo Kazuhiro Hanazaki |
| author_facet | Hiromichi Maeda Michiko Takahashi Satoru Seo Kazuhiro Hanazaki |
| author_sort | Hiromichi Maeda |
| collection | DOAJ |
| description | Frailty is characterized by reduced physiological reserves across multiple systems. In patients with frailty, oncological surgery has been associated with a high rate of postoperative complications and worse overall survival. Further, given that cancer and frailty can co-exist in the same patient, cancer and cancer-related symptoms can rapidly accelerate the progression of baseline frailty, which we have termed “cancer frailty”. This distinction is clinically meaningful because the prioritization of interventions and the treatment outcomes may differ based on health conditions. Specifically, in patients with cancer frailty, improvements in frailty may be achieved via surgical removal of tumors, while prehabilitation may be less effective, which may in turn result in delayed treatment and cancer progression. In this review, we focused on challenges in the surgical treatment of non-metastatic colorectal cancers in patients with frailty, including those related to decision making, prehabilitation, and surgery. Potential recommendations for treating patients with cancer frailty are also discussed. |
| first_indexed | 2024-03-11T00:24:22Z |
| format | Article |
| id | doaj.art-5ebd9267b45543f2ad2c2d9cb6cb2fef |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:22Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5ebd9267b45543f2ad2c2d9cb6cb2fef2023-11-18T23:08:38ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215504110.3390/jcm12155041Frailty and Colorectal Surgery: Review and Concept of Cancer FrailtyHiromichi Maeda0Michiko Takahashi1Satoru Seo2Kazuhiro Hanazaki3Department of Surgery, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku 783-8505, JapanDepartment of Surgery, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku 783-8505, JapanDepartment of Surgery, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku 783-8505, JapanDepartment of Surgery, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku 783-8505, JapanFrailty is characterized by reduced physiological reserves across multiple systems. In patients with frailty, oncological surgery has been associated with a high rate of postoperative complications and worse overall survival. Further, given that cancer and frailty can co-exist in the same patient, cancer and cancer-related symptoms can rapidly accelerate the progression of baseline frailty, which we have termed “cancer frailty”. This distinction is clinically meaningful because the prioritization of interventions and the treatment outcomes may differ based on health conditions. Specifically, in patients with cancer frailty, improvements in frailty may be achieved via surgical removal of tumors, while prehabilitation may be less effective, which may in turn result in delayed treatment and cancer progression. In this review, we focused on challenges in the surgical treatment of non-metastatic colorectal cancers in patients with frailty, including those related to decision making, prehabilitation, and surgery. Potential recommendations for treating patients with cancer frailty are also discussed.https://www.mdpi.com/2077-0383/12/15/5041gastrointestinal surgerycancer frailtyprehabilitationdecision making |
| spellingShingle | Hiromichi Maeda Michiko Takahashi Satoru Seo Kazuhiro Hanazaki Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty Journal of Clinical Medicine gastrointestinal surgery cancer frailty prehabilitation decision making |
| title | Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty |
| title_full | Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty |
| title_fullStr | Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty |
| title_full_unstemmed | Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty |
| title_short | Frailty and Colorectal Surgery: Review and Concept of Cancer Frailty |
| title_sort | frailty and colorectal surgery review and concept of cancer frailty |
| topic | gastrointestinal surgery cancer frailty prehabilitation decision making |
| url | https://www.mdpi.com/2077-0383/12/15/5041 |
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