Reno-Protective Effect of GLP-1 Receptor Agonists in Type1 Diabetes: Dual Action on TRPC6 and NADPH Oxidases

Reno-Protective Effect of GLP-1 Receptor Agonists in Type1 Diabetes: Dual Action on TRPC6 and NADPH Oxidases

Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production. DUOX1 and 2 are NOX enzymes that require calcium for their activation which enters renal cells through the pivotal TRPC channels. Hypoglycemi...

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Bibliographic Details
Main Authors: Natalie Youssef, Mohamed Noureldein, Rachel Njeim, Hilda E. Ghadieh, Frederic Harb, Sami T. Azar, Nassim Fares, Assaad A. Eid
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
diabetic kidney disease
DUOX1/2
TRPC6
GLP-1
liraglutide
Online Access:https://www.mdpi.com/2227-9059/9/10/1360

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