Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma
Pur po se: To compare the effect of trabeculectomy with mitomycin C (mit C) on central macular thickness (CMT) in primary openangle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). Ma te ri al and Met hod: 13 eyes with PXG and 11 eyes with POAG, which had undergone trabeculectomy with mit C,...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2012-01-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/article_2114/Comparison-Of-The-Effect-Of-Trabeculectomy-With-Mitomycin-C-On-Macular-Thickness-In-Primary-Open-angle-Glaucoma-And-Pseudoexfoliative-Glaucoma |
| _version_ | 1797912918535176192 |
|---|---|
| author | Ufuk Elgin Emine Şen Hakan Tırhış |
| author_facet | Ufuk Elgin Emine Şen Hakan Tırhış |
| author_sort | Ufuk Elgin |
| collection | DOAJ |
| description | Pur po se: To compare the effect of trabeculectomy with mitomycin C (mit C) on central macular thickness (CMT) in primary openangle
glaucoma (POAG) and pseudoexfoliative glaucoma (PXG).
Ma te ri al and Met hod: 13 eyes with PXG and 11 eyes with POAG, which had undergone trabeculectomy with mit C, were included
to our prospective study. Cases with histories of any systemic vascular diseases and previous ocular surgeries were not included. The
CMT was measured by spectral-domain optical coherence tomography (SD-OCT) before the surgery and at the first postoperative week
and month. Pre-and postoperative values of both groups and the differences between the two groups were compared statistically by
Mann-Whitney U and Wilcoxon signed rank tests.
Re sults: The means of CMT at the first postoperative week and month were statistically significantly higher than the preoperative
values in both POAG and PXG groups (POAG: 1st week p=0.0090, 1st month p=0.0086; PXG: 1st week p=0.0023, 1st month
p=0.0050). However, no statistically significant differences were found between the changes of preoperative and postoperative mean
CMT values between the two groups (1st week p=0.4326, 1st month p=0.5028).
Dis cus si on: In spite of the increases in CMT at the 1st week and month of trabeculectomy with mit C in POAG and PXG, no significant
differences were detected between the changes of CMT between the two groups. Based on the fact that more inflammation and higher
decrease in intraocular pressure might be seen in PXG than POAG postoperatively, further investigations with great number of cases are
planned. (Turk J Ophthalmol 2012; 42: 1-4) |
| first_indexed | 2024-04-10T12:03:34Z |
| format | Article |
| id | doaj.art-5ebfd422107a4b8885d2898353c67992 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T12:03:34Z |
| publishDate | 2012-01-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-5ebfd422107a4b8885d2898353c679922023-02-15T16:16:24ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612012-01-014211410.4274/tjo.42.58077Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative GlaucomaUfuk Elgin0Emine Şen1Hakan Tırhış2S.B. Ulucanlar Göz Eğitim Hastanesi, Ankara, TürkiyeS.B. Ulucanlar Göz Eğitim Hastanesi, Ankara, TürkiyeS.B. Ulucanlar Göz Eğitim Hastanesi, Ankara, TürkiyeS.B. Ulucanlar Göz Eğitim Hastanesi, Ankara, TürkiyePur po se: To compare the effect of trabeculectomy with mitomycin C (mit C) on central macular thickness (CMT) in primary openangle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). Ma te ri al and Met hod: 13 eyes with PXG and 11 eyes with POAG, which had undergone trabeculectomy with mit C, were included to our prospective study. Cases with histories of any systemic vascular diseases and previous ocular surgeries were not included. The CMT was measured by spectral-domain optical coherence tomography (SD-OCT) before the surgery and at the first postoperative week and month. Pre-and postoperative values of both groups and the differences between the two groups were compared statistically by Mann-Whitney U and Wilcoxon signed rank tests. Re sults: The means of CMT at the first postoperative week and month were statistically significantly higher than the preoperative values in both POAG and PXG groups (POAG: 1st week p=0.0090, 1st month p=0.0086; PXG: 1st week p=0.0023, 1st month p=0.0050). However, no statistically significant differences were found between the changes of preoperative and postoperative mean CMT values between the two groups (1st week p=0.4326, 1st month p=0.5028). Dis cus si on: In spite of the increases in CMT at the 1st week and month of trabeculectomy with mit C in POAG and PXG, no significant differences were detected between the changes of CMT between the two groups. Based on the fact that more inflammation and higher decrease in intraocular pressure might be seen in PXG than POAG postoperatively, further investigations with great number of cases are planned. (Turk J Ophthalmol 2012; 42: 1-4)http://www.oftalmoloji.org/article_2114/Comparison-Of-The-Effect-Of-Trabeculectomy-With-Mitomycin-C-On-Macular-Thickness-In-Primary-Open-angle-Glaucoma-And-Pseudoexfoliative-GlaucomaPrimary open-angle glaucomapseudoexfoliative glaucomacentral macular thicknesstrabeculectomyoptical coherence tomography |
| spellingShingle | Ufuk Elgin Emine Şen Hakan Tırhış Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma Türk Oftalmoloji Dergisi Primary open-angle glaucoma pseudoexfoliative glaucoma central macular thickness trabeculectomy optical coherence tomography |
| title | Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma |
| title_full | Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma |
| title_fullStr | Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma |
| title_full_unstemmed | Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma |
| title_short | Comparison of the Effect of Trabeculectomy with Mitomycin C on Macular Thickness in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma |
| title_sort | comparison of the effect of trabeculectomy with mitomycin c on macular thickness in primary open angle glaucoma and pseudoexfoliative glaucoma |
| topic | Primary open-angle glaucoma pseudoexfoliative glaucoma central macular thickness trabeculectomy optical coherence tomography |
| url | http://www.oftalmoloji.org/article_2114/Comparison-Of-The-Effect-Of-Trabeculectomy-With-Mitomycin-C-On-Macular-Thickness-In-Primary-Open-angle-Glaucoma-And-Pseudoexfoliative-Glaucoma |
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