Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment
Overcoming resistance to apoptosis is a major challenge in cancer therapy. Recent research has shown that manipulating mitochondria, the organelles critical for energy metabolism in tumor cells, can increase the effectiveness of photodynamic therapy and trigger apoptosis in tumor cells. However, the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1338257/full |
| _version_ | 1827378874787299328 |
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| author | Letian Lv Letian Lv Zhao Fu Qing You Wei Xiao Huayi Wang Chen Wang Chen Wang Yanlian Yang Yanlian Yang |
| author_facet | Letian Lv Letian Lv Zhao Fu Qing You Wei Xiao Huayi Wang Chen Wang Chen Wang Yanlian Yang Yanlian Yang |
| author_sort | Letian Lv |
| collection | DOAJ |
| description | Overcoming resistance to apoptosis is a major challenge in cancer therapy. Recent research has shown that manipulating mitochondria, the organelles critical for energy metabolism in tumor cells, can increase the effectiveness of photodynamic therapy and trigger apoptosis in tumor cells. However, there is currently insufficient research and effective methods to exploit mitochondrial damage to induce apoptosis in tumor cells and improve the effectiveness of photodynamic therapy. In this study, we present a novel nanomedicine delivery and therapeutic system called PyroFPSH, which utilizes a nanozymes-modified metal-organic framework as a carrier. PyroFPSH exhibits remarkable multienzyme-like activities, including glutathione peroxidase (GPx) and catalase (CAT) mimicry, allowing it to overcome apoptosis resistance, reduce endogenous glutathione levels, and continuously generate reactive oxygen species (ROS). In addition, PyroFPSH can serve as a carrier for the targeted delivery of sulfasalazine, a drug that can induce mitochondrial depolarization in tumor cells, thereby reducing oxygen consumption and energy supply in the mitochondria of tumor cells and weakening resistance to other synergistic treatment approaches. Our experimental results highlight the potential of PyroFPSH as a versatile nanoplatform in cancer treatment. This study expands the biomedical applications of nanomaterials as platforms and enables the integration of various novel therapeutic strategies to synergistically improve tumor therapy. It deepens our understanding of multienzyme-mimicking active nanocarriers and mitochondrial damage through photodynamic therapy. Future research can further explore the potential of PyroFPSH in clinical cancer treatment and improve its drug loading capacity, biocompatibility and targeting specificity. In summary, PyroFPSH represents a promising therapeutic approach that can provide new insights and possibilities for cancer treatment. |
| first_indexed | 2024-03-08T13:03:12Z |
| format | Article |
| id | doaj.art-5ec187c8f14e47aca712487647a37a3f |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T13:03:12Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5ec187c8f14e47aca712487647a37a3f2024-01-19T04:12:47ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011110.3389/fbioe.2023.13382571338257Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatmentLetian Lv0Letian Lv1Zhao Fu2Qing You3Wei Xiao4Huayi Wang5Chen Wang6Chen Wang7Yanlian Yang8Yanlian Yang9CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaOvercoming resistance to apoptosis is a major challenge in cancer therapy. Recent research has shown that manipulating mitochondria, the organelles critical for energy metabolism in tumor cells, can increase the effectiveness of photodynamic therapy and trigger apoptosis in tumor cells. However, there is currently insufficient research and effective methods to exploit mitochondrial damage to induce apoptosis in tumor cells and improve the effectiveness of photodynamic therapy. In this study, we present a novel nanomedicine delivery and therapeutic system called PyroFPSH, which utilizes a nanozymes-modified metal-organic framework as a carrier. PyroFPSH exhibits remarkable multienzyme-like activities, including glutathione peroxidase (GPx) and catalase (CAT) mimicry, allowing it to overcome apoptosis resistance, reduce endogenous glutathione levels, and continuously generate reactive oxygen species (ROS). In addition, PyroFPSH can serve as a carrier for the targeted delivery of sulfasalazine, a drug that can induce mitochondrial depolarization in tumor cells, thereby reducing oxygen consumption and energy supply in the mitochondria of tumor cells and weakening resistance to other synergistic treatment approaches. Our experimental results highlight the potential of PyroFPSH as a versatile nanoplatform in cancer treatment. This study expands the biomedical applications of nanomaterials as platforms and enables the integration of various novel therapeutic strategies to synergistically improve tumor therapy. It deepens our understanding of multienzyme-mimicking active nanocarriers and mitochondrial damage through photodynamic therapy. Future research can further explore the potential of PyroFPSH in clinical cancer treatment and improve its drug loading capacity, biocompatibility and targeting specificity. In summary, PyroFPSH represents a promising therapeutic approach that can provide new insights and possibilities for cancer treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1338257/fullphotodynamic therapyMOFnanozymemulti-functional nanoplatformcombination therapy |
| spellingShingle | Letian Lv Letian Lv Zhao Fu Qing You Wei Xiao Huayi Wang Chen Wang Chen Wang Yanlian Yang Yanlian Yang Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment Frontiers in Bioengineering and Biotechnology photodynamic therapy MOF nanozyme multi-functional nanoplatform combination therapy |
| title | Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment |
| title_full | Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment |
| title_fullStr | Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment |
| title_full_unstemmed | Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment |
| title_short | Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment |
| title_sort | enhanced photodynamic therapy through multienzyme like mof for cancer treatment |
| topic | photodynamic therapy MOF nanozyme multi-functional nanoplatform combination therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1338257/full |
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