Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners
OBJECTIVES: Human immunodeficiency virus-positive (HIV+) individuals can experience a decrease in antioxidants. Such deficiency can make inner ear cells and synapses more vulnerable to oxidative stress, resulting in auditory alterations, even in the presence of normal thresholds. This study aims to...
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| Format: | Article |
| Language: | English |
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Elsevier España
2020-11-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100306&tlng=en |
| _version_ | 1818115938153660416 |
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| author | Carla G. Matas Fernanda Yasmin OMM Padilha Rosanna MG Angrisani Alessandra G. Samelli |
| author_facet | Carla G. Matas Fernanda Yasmin OMM Padilha Rosanna MG Angrisani Alessandra G. Samelli |
| author_sort | Carla G. Matas |
| collection | DOAJ |
| description | OBJECTIVES: Human immunodeficiency virus-positive (HIV+) individuals can experience a decrease in antioxidants. Such deficiency can make inner ear cells and synapses more vulnerable to oxidative stress, resulting in auditory alterations, even in the presence of normal thresholds. This study aims to compare the audiological findings of HIV+ patients (with and without exposure to anti-retroviral treatment) to those of healthy individuals. METHODS: This was a cross-sectional observational study, comprising 42 normal-hearing adults divided into the Control Group (CG), without HIV; Group I (GI), HIV+, without exposure to the highly active anti-retroviral therapy (HAART); Group II (GII), HIV+, with exposure to HAART. All participants underwent conventional audiometry (0.25-8 kHz), high-frequency audiometry (9-20 kHz), transient evoked otoacoustic emissions (TEOAEs), efferent auditory pathway’s inhibitory effect assessment, brainstem auditory evoked potentials (BAEPs), and cognitive potential (P300). RESULTS: In the comparison of the hearing thresholds between the groups, there was a statistically significant difference for most of the frequencies assessed (GII presented hearing thresholds significantly poor when compared with other groups). The presence of TEOAE and the inhibitory effect was also verified in a significantly higher number of individuals in the CG than in the other groups. As for the BAEP, there was a statistically significant difference for the interpeak intervals I-V (GII showed higher values when compared with CG). For P300, there were no statistically significant differences. CONCLUSION: Normal-hearing HIV+ individuals (with and without exposure to HAART) presented with poor performance in the audiological procedures, suggesting the presence of auditory alterations even in the presence of normal-hearing thresholds. |
| first_indexed | 2024-12-11T04:14:34Z |
| format | Article |
| id | doaj.art-5ec30418bf5d441e8b856182fc4b51d0 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T04:14:34Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-5ec30418bf5d441e8b856182fc4b51d02022-12-22T01:21:17ZengElsevier EspañaClinics1980-53222020-11-017510.6061/clinics/2020/e1845Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal ListenersCarla G. Matashttps://orcid.org/0000-0002-9408-7172Fernanda Yasmin OMM Padilhahttps://orcid.org/0000-0003-4780-5423Rosanna MG Angrisanihttps://orcid.org/0000-0001-8742-7450Alessandra G. Samellihttps://orcid.org/0000-0002-7164-8942OBJECTIVES: Human immunodeficiency virus-positive (HIV+) individuals can experience a decrease in antioxidants. Such deficiency can make inner ear cells and synapses more vulnerable to oxidative stress, resulting in auditory alterations, even in the presence of normal thresholds. This study aims to compare the audiological findings of HIV+ patients (with and without exposure to anti-retroviral treatment) to those of healthy individuals. METHODS: This was a cross-sectional observational study, comprising 42 normal-hearing adults divided into the Control Group (CG), without HIV; Group I (GI), HIV+, without exposure to the highly active anti-retroviral therapy (HAART); Group II (GII), HIV+, with exposure to HAART. All participants underwent conventional audiometry (0.25-8 kHz), high-frequency audiometry (9-20 kHz), transient evoked otoacoustic emissions (TEOAEs), efferent auditory pathway’s inhibitory effect assessment, brainstem auditory evoked potentials (BAEPs), and cognitive potential (P300). RESULTS: In the comparison of the hearing thresholds between the groups, there was a statistically significant difference for most of the frequencies assessed (GII presented hearing thresholds significantly poor when compared with other groups). The presence of TEOAE and the inhibitory effect was also verified in a significantly higher number of individuals in the CG than in the other groups. As for the BAEP, there was a statistically significant difference for the interpeak intervals I-V (GII showed higher values when compared with CG). For P300, there were no statistically significant differences. CONCLUSION: Normal-hearing HIV+ individuals (with and without exposure to HAART) presented with poor performance in the audiological procedures, suggesting the presence of auditory alterations even in the presence of normal-hearing thresholds.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100306&tlng=enHIVHearingHearing DisordersOxidative StressHearing Tests |
| spellingShingle | Carla G. Matas Fernanda Yasmin OMM Padilha Rosanna MG Angrisani Alessandra G. Samelli Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners Clinics HIV Hearing Hearing Disorders Oxidative Stress Hearing Tests |
| title | Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners |
| title_full | Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners |
| title_fullStr | Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners |
| title_full_unstemmed | Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners |
| title_short | Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners |
| title_sort | oxidative stress as a risk factor for hearing changes in hiv positive normal listeners |
| topic | HIV Hearing Hearing Disorders Oxidative Stress Hearing Tests |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100306&tlng=en |
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