Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association
Background: The increasing incidence of hepatocellular carcinoma (HCC) is a challenging health problem worldwide with poor prognosis and limited treatment options. The association between metabolic factors and HCC has been documented, however, there is a shortage of data about this association in ou...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-04-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | https://mejc.sums.ac.ir/article_47626_5a2d43acabe3654a98914d45a15053eb.pdf |
| _version_ | 1818201197724565504 |
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| author | Ehab Moustafa Elham Hassan Mohamed Mahmoud Amal Mahmoud Mohamed Ghaliony |
| author_facet | Ehab Moustafa Elham Hassan Mohamed Mahmoud Amal Mahmoud Mohamed Ghaliony |
| author_sort | Ehab Moustafa |
| collection | DOAJ |
| description | Background: The increasing incidence of hepatocellular carcinoma (HCC) is a challenging health problem worldwide with poor prognosis and limited treatment options. The association between metabolic factors and HCC has been documented, however, there is a shortage of data about this association in our locality. Therefore, we aimed to determine the pattern of lipid profile in cirrhotic patients with HCC and investigate the association between dyslipidemia and HCC. Method: In this case-control hospital-based study, serum lipid profile [total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL)] was determined in 100 patients with cirrhosis and 100 patients with cirrhosis and HCC. Multivariate analysis of HCC risk factors was done. Results: Metabolic syndrome, hypertriglyceridemia, hypercholesterolemia, high LDL, and combined dyslipidemia were significantly more frequent in HCC patients than non-HCC patients. Low HDL and dyslipidemia were significantly associated with the late HCC stages and LDL levels were significantly correlated with α- fetoprotein levels. There was a tendency towards increasing the values of the other lipid parameters in advanced stages. Metabolic syndrome and combined dyslipidemia were associated with HCC risk. Conclusion: Deranged lipid profiles were common in HCC patients. Metabolic syndrome and combined dyslipidemia could be potential risk factors for HCC and may offer a useful strategy for risk stratification; thus, their control can reduce the HCC burden. |
| first_indexed | 2024-12-12T02:49:44Z |
| format | Article |
| id | doaj.art-5ec3157d43344469b32b08ed83227427 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-12T02:49:44Z |
| publishDate | 2022-04-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-5ec3157d43344469b32b08ed832274272022-12-22T00:40:55ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872022-04-0113227528410.30476/mejc.2021.86476.134647626Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and AssociationEhab Moustafa0Elham Hassan1Mohamed Mahmoud2Amal Mahmoud3Mohamed Ghaliony4Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, EgyptFever Hospital, Ministry of Health, Sohag, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, EgyptBackground: The increasing incidence of hepatocellular carcinoma (HCC) is a challenging health problem worldwide with poor prognosis and limited treatment options. The association between metabolic factors and HCC has been documented, however, there is a shortage of data about this association in our locality. Therefore, we aimed to determine the pattern of lipid profile in cirrhotic patients with HCC and investigate the association between dyslipidemia and HCC. Method: In this case-control hospital-based study, serum lipid profile [total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL)] was determined in 100 patients with cirrhosis and 100 patients with cirrhosis and HCC. Multivariate analysis of HCC risk factors was done. Results: Metabolic syndrome, hypertriglyceridemia, hypercholesterolemia, high LDL, and combined dyslipidemia were significantly more frequent in HCC patients than non-HCC patients. Low HDL and dyslipidemia were significantly associated with the late HCC stages and LDL levels were significantly correlated with α- fetoprotein levels. There was a tendency towards increasing the values of the other lipid parameters in advanced stages. Metabolic syndrome and combined dyslipidemia were associated with HCC risk. Conclusion: Deranged lipid profiles were common in HCC patients. Metabolic syndrome and combined dyslipidemia could be potential risk factors for HCC and may offer a useful strategy for risk stratification; thus, their control can reduce the HCC burden.https://mejc.sums.ac.ir/article_47626_5a2d43acabe3654a98914d45a15053eb.pdfdyslipidemiashepatocellular carcinoma (hcc)metabolic syndromerisk factors |
| spellingShingle | Ehab Moustafa Elham Hassan Mohamed Mahmoud Amal Mahmoud Mohamed Ghaliony Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association Middle East Journal of Cancer dyslipidemias hepatocellular carcinoma (hcc) metabolic syndrome risk factors |
| title | Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association |
| title_full | Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association |
| title_fullStr | Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association |
| title_full_unstemmed | Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association |
| title_short | Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association |
| title_sort | deranged lipid profiles and hepatocellular carcinoma clinical significance and association |
| topic | dyslipidemias hepatocellular carcinoma (hcc) metabolic syndrome risk factors |
| url | https://mejc.sums.ac.ir/article_47626_5a2d43acabe3654a98914d45a15053eb.pdf |
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