Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population
In December 2014, a novel foot and mouth disease (FMD) virus was introduced to a pig farm in South Korea, despite the animals being vaccinated. A marginal antigenic matching between the novel and vaccine strains potentially led to the infection of the vaccinated animals. To understand the impact of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/19/3082 |
| _version_ | 1827722881448017920 |
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| author | Jun-Hee Han Dae-Sung Yoo Chang-Min Lee |
| author_facet | Jun-Hee Han Dae-Sung Yoo Chang-Min Lee |
| author_sort | Jun-Hee Han |
| collection | DOAJ |
| description | In December 2014, a novel foot and mouth disease (FMD) virus was introduced to a pig farm in South Korea, despite the animals being vaccinated. A marginal antigenic matching between the novel and vaccine strains potentially led to the infection of the vaccinated animals. To understand the impact of using an FMD vaccine on the transmission dynamics of an unmatched field strain, simulation models were employed using daily reported data on clinical cases from the farm. The results of this study indicated that immunisation with the FMD vaccine reduced the shedding of the novel FMD virus in pigs. However, there was no evidence to suggest that the immunisation had a significant effect in reducing the development of clinical signs. These findings highlight that the use of an unmatched FMD vaccine can confound the outbreak by altering the disease dynamics of the novel virus. Based on this study, we emphasise the importance of continuous testing to ensure antigenic matching between the circulating strains and the vaccine pool. |
| first_indexed | 2024-03-10T21:50:32Z |
| format | Article |
| id | doaj.art-5ec4091f79ef458480cb0df0f64d254e |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T21:50:32Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-5ec4091f79ef458480cb0df0f64d254e2023-11-19T13:59:59ZengMDPI AGAnimals2076-26152023-10-011319308210.3390/ani13193082Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig PopulationJun-Hee Han0Dae-Sung Yoo1Chang-Min Lee2EpiCentre, School of Veterinary Science, Massey University, Palmerston North 4410, New ZealandCollege of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaCollege of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of KoreaIn December 2014, a novel foot and mouth disease (FMD) virus was introduced to a pig farm in South Korea, despite the animals being vaccinated. A marginal antigenic matching between the novel and vaccine strains potentially led to the infection of the vaccinated animals. To understand the impact of using an FMD vaccine on the transmission dynamics of an unmatched field strain, simulation models were employed using daily reported data on clinical cases from the farm. The results of this study indicated that immunisation with the FMD vaccine reduced the shedding of the novel FMD virus in pigs. However, there was no evidence to suggest that the immunisation had a significant effect in reducing the development of clinical signs. These findings highlight that the use of an unmatched FMD vaccine can confound the outbreak by altering the disease dynamics of the novel virus. Based on this study, we emphasise the importance of continuous testing to ensure antigenic matching between the circulating strains and the vaccine pool.https://www.mdpi.com/2076-2615/13/19/3082foot and mouth diseaseunmatched vaccineantigenic diversityvaccine effectABC-SMC |
| spellingShingle | Jun-Hee Han Dae-Sung Yoo Chang-Min Lee Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population Animals foot and mouth disease unmatched vaccine antigenic diversity vaccine effect ABC-SMC |
| title | Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population |
| title_full | Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population |
| title_fullStr | Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population |
| title_full_unstemmed | Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population |
| title_short | Effect of a Mismatched Vaccine against the Outbreak of a Novel FMD Strain in a Pig Population |
| title_sort | effect of a mismatched vaccine against the outbreak of a novel fmd strain in a pig population |
| topic | foot and mouth disease unmatched vaccine antigenic diversity vaccine effect ABC-SMC |
| url | https://www.mdpi.com/2076-2615/13/19/3082 |
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