Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review
Study objective: The present systematic review investigates the hypothesis that specific components of the intestinal microbiome and/or their metabolites are associated with early stages of subclinical arterial damage (SAD). Design: Based on the MOOSE criteria, we conducted a systematic review of th...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
|
| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602222001367 |
| _version_ | 1798022987687919616 |
|---|---|
| author | Konstantinos Grammatopoulos Vaios-Dionysios Antoniou Evangelos Mavrothalassitis Dimitris Mouziouras Antonios A. Argyris Eleni Emmanouil Charalampos Vlachopoulos Athanase D. Protogerou |
| author_facet | Konstantinos Grammatopoulos Vaios-Dionysios Antoniou Evangelos Mavrothalassitis Dimitris Mouziouras Antonios A. Argyris Eleni Emmanouil Charalampos Vlachopoulos Athanase D. Protogerou |
| author_sort | Konstantinos Grammatopoulos |
| collection | DOAJ |
| description | Study objective: The present systematic review investigates the hypothesis that specific components of the intestinal microbiome and/or their metabolites are associated with early stages of subclinical arterial damage (SAD). Design: Based on the MOOSE criteria, we conducted a systematic review of the literature (Scopus, Medline) investigating the potential association between gut microbiota and the most widely applied arterial biomarkers of SAD. Participants: All studies included individuals without established cardiovascular disease, either with or without SAD. Intervention: No interventions were made. Main outcome measures: Association between exposure (components/metabolites of microbiota) and outcome (presence of SAD). Results: Fourteen articles met the predefined criteria. Due to the large heterogeneity, their meta-analysis was not possible. Our review revealed (a) two studies on endothelial dysfunction, out of which one found an inverse relation between plasma trimethylamine N-oxide levels and FMD and the other did not substantiate a statistically significant correlation with RHI. (b) Twelve studies on atheromatosis, assessed as intimal-medial thickness (IMT), coronary artery calcium (CAC) and arterial plaque, of which, seven studies showed statistically significant associations (negative or positive depending on the microorganism or microbiota metabolite) with IMT, one study revealed significant associations with coronary artery calcium, while one showed absence of correlation and four studies reported statistically significant correlations with arterial plaque. (c) Three studies on arterial stiffness (pulse wave velocity - PWV) with two of them concluding in statistically significant association while the third study did not. Some articles investigated multiple of the correlations described and therefore, belonged to more than one section. Conclusion: Evidence of both positive and inverse associations of gut microbiota composition and their metabolites with different types of SVD has been found. However the small number and heterogeneity of available studies cannot allow to confirm or disprove the hypothesis. |
| first_indexed | 2024-04-11T17:38:52Z |
| format | Article |
| id | doaj.art-5ec42a4a25de4ac0a42549aed5a925ef |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-11T17:38:52Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-5ec42a4a25de4ac0a42549aed5a925ef2022-12-22T04:11:33ZengElsevierAmerican Heart Journal Plus2666-60222022-11-0123100219Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic reviewKonstantinos Grammatopoulos0Vaios-Dionysios Antoniou1Evangelos Mavrothalassitis2Dimitris Mouziouras3Antonios A. Argyris4Eleni Emmanouil5Charalampos Vlachopoulos6Athanase D. Protogerou7Cardiovascular Prevention and Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, GreeceCardiovascular Prevention and Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, GreeceCardiovascular Prevention and Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, GreeceCardiovascular Prevention and Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, GreeceCardiovascular Prevention and Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Greece1st Department of Cardiology, National and Kapodistrian University of Athens, Greece1st Department of Cardiology, National and Kapodistrian University of Athens, GreeceCardiovascular Prevention and Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Greece; Corresponding author at: Cardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, 75, Mikras Asias Street (Building 16, 3rd floor, room 8), 115 27 Athens, Greece.Study objective: The present systematic review investigates the hypothesis that specific components of the intestinal microbiome and/or their metabolites are associated with early stages of subclinical arterial damage (SAD). Design: Based on the MOOSE criteria, we conducted a systematic review of the literature (Scopus, Medline) investigating the potential association between gut microbiota and the most widely applied arterial biomarkers of SAD. Participants: All studies included individuals without established cardiovascular disease, either with or without SAD. Intervention: No interventions were made. Main outcome measures: Association between exposure (components/metabolites of microbiota) and outcome (presence of SAD). Results: Fourteen articles met the predefined criteria. Due to the large heterogeneity, their meta-analysis was not possible. Our review revealed (a) two studies on endothelial dysfunction, out of which one found an inverse relation between plasma trimethylamine N-oxide levels and FMD and the other did not substantiate a statistically significant correlation with RHI. (b) Twelve studies on atheromatosis, assessed as intimal-medial thickness (IMT), coronary artery calcium (CAC) and arterial plaque, of which, seven studies showed statistically significant associations (negative or positive depending on the microorganism or microbiota metabolite) with IMT, one study revealed significant associations with coronary artery calcium, while one showed absence of correlation and four studies reported statistically significant correlations with arterial plaque. (c) Three studies on arterial stiffness (pulse wave velocity - PWV) with two of them concluding in statistically significant association while the third study did not. Some articles investigated multiple of the correlations described and therefore, belonged to more than one section. Conclusion: Evidence of both positive and inverse associations of gut microbiota composition and their metabolites with different types of SVD has been found. However the small number and heterogeneity of available studies cannot allow to confirm or disprove the hypothesis.http://www.sciencedirect.com/science/article/pii/S2666602222001367Gut microbiotaIntestinal microbiotaGut microbiota metaboliteEndothelial dysfunctionAtheromatosisArterial stiffness |
| spellingShingle | Konstantinos Grammatopoulos Vaios-Dionysios Antoniou Evangelos Mavrothalassitis Dimitris Mouziouras Antonios A. Argyris Eleni Emmanouil Charalampos Vlachopoulos Athanase D. Protogerou Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review American Heart Journal Plus Gut microbiota Intestinal microbiota Gut microbiota metabolite Endothelial dysfunction Atheromatosis Arterial stiffness |
| title | Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review |
| title_full | Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review |
| title_fullStr | Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review |
| title_full_unstemmed | Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review |
| title_short | Association of gut microbiota composition and their metabolites with subclinical atheromatosis: A systematic review |
| title_sort | association of gut microbiota composition and their metabolites with subclinical atheromatosis a systematic review |
| topic | Gut microbiota Intestinal microbiota Gut microbiota metabolite Endothelial dysfunction Atheromatosis Arterial stiffness |
| url | http://www.sciencedirect.com/science/article/pii/S2666602222001367 |
| work_keys_str_mv | AT konstantinosgrammatopoulos associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT vaiosdionysiosantoniou associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT evangelosmavrothalassitis associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT dimitrismouziouras associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT antoniosaargyris associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT eleniemmanouil associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT charalamposvlachopoulos associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview AT athanasedprotogerou associationofgutmicrobiotacompositionandtheirmetaboliteswithsubclinicalatheromatosisasystematicreview |