Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
Chukwuma Iwundu, Dong Pang, Yannis Pappas Institute for Health Research, University of Bedfordshire, Luton, UKCorrespondence: Chukwuma IwunduInstitute for Health Research, University of Bedfordshire, Luton, Bedfordshire LU2 8LE, UKTel +44 1582 743797Fax +44 1582 743918Email Chukwuma.iwundu@study.bed...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-10-01
|
| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/childhood-maternal-school-leaving-age-level-of-education-and-risk-mark-peer-reviewed-article-DMSO |
| _version_ | 1797935967439421440 |
|---|---|
| author | Iwundu C Pang D Pappas Y |
| author_facet | Iwundu C Pang D Pappas Y |
| author_sort | Iwundu C |
| collection | DOAJ |
| description | Chukwuma Iwundu, Dong Pang, Yannis Pappas Institute for Health Research, University of Bedfordshire, Luton, UKCorrespondence: Chukwuma IwunduInstitute for Health Research, University of Bedfordshire, Luton, Bedfordshire LU2 8LE, UKTel +44 1582 743797Fax +44 1582 743918Email Chukwuma.iwundu@study.beds.ac.ukPurpose: The aim of this study is to investigate the relationship between childhood maternal level of education (CMLE) and changes in anthropometric and laboratory risk markers of metabolic syndrome (MetS) in mid-adulthood using results from the 1958 British Birth Cohort Study.Design: Cohort study.Participants: A total of 9376 study samples consisting of subjects that participated in the biomedical survey of the national child development study (NCDS) carried out between 2002 and 2004 were used for the analysis.Main Outcome Measures: Five risk markers of MetS: (i) HDL-cholesterol (ii) triglyceride (iii) blood pressure (BP) including systolic (SBP) and diastolic (DBP) (iv) waist circumference (WC) and (v) glycated haemoglobin (HbA1c).Methods: The NCDS or the 1958 British birth cohort data deposited in the UK data service by the centre for longitudinal studies were used for analyses. Ordinary least squares regression was used to determine unit changes in the outcome variables given CMLE.Results: The estimates for unadjusted regression analysis of individual risk markers indicated a significant relationship between CMLE and alterations in the five risk markers of MetS (HDL-cholesterol, triglyceride, WC, HbA1c, and BP) in midlife. After adjustment for birth and lifestyle characteristics/health behaviours, the relationship between CMLE and the risk markers was attenuated for HDL-cholesterol, triglycerides, and HbA1c but remained significant for WC 0.70 (95% confidence interval (CI) 0.065– 1.30, p< 0.001) and SBP 1.48 (95% CI 0.48– 2.47 p< 0.001).Conclusion: There was a positive association between lower CMLE and the risk of MetS using the NCDS data. Lifestyle characteristics may be influential determinants of MetS risk in mid-adulthood.Keywords: maternal education, metabolic syndrome, risk markers, biomedical survey, NCDS data |
| first_indexed | 2024-04-10T18:23:22Z |
| format | Article |
| id | doaj.art-5ec4c4b9a36b47ca8764980a9a78b184 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:23:22Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-5ec4c4b9a36b47ca8764980a9a78b1842023-02-02T06:48:41ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-10-01Volume 133761377158208Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth CohortIwundu CPang DPappas YChukwuma Iwundu, Dong Pang, Yannis Pappas Institute for Health Research, University of Bedfordshire, Luton, UKCorrespondence: Chukwuma IwunduInstitute for Health Research, University of Bedfordshire, Luton, Bedfordshire LU2 8LE, UKTel +44 1582 743797Fax +44 1582 743918Email Chukwuma.iwundu@study.beds.ac.ukPurpose: The aim of this study is to investigate the relationship between childhood maternal level of education (CMLE) and changes in anthropometric and laboratory risk markers of metabolic syndrome (MetS) in mid-adulthood using results from the 1958 British Birth Cohort Study.Design: Cohort study.Participants: A total of 9376 study samples consisting of subjects that participated in the biomedical survey of the national child development study (NCDS) carried out between 2002 and 2004 were used for the analysis.Main Outcome Measures: Five risk markers of MetS: (i) HDL-cholesterol (ii) triglyceride (iii) blood pressure (BP) including systolic (SBP) and diastolic (DBP) (iv) waist circumference (WC) and (v) glycated haemoglobin (HbA1c).Methods: The NCDS or the 1958 British birth cohort data deposited in the UK data service by the centre for longitudinal studies were used for analyses. Ordinary least squares regression was used to determine unit changes in the outcome variables given CMLE.Results: The estimates for unadjusted regression analysis of individual risk markers indicated a significant relationship between CMLE and alterations in the five risk markers of MetS (HDL-cholesterol, triglyceride, WC, HbA1c, and BP) in midlife. After adjustment for birth and lifestyle characteristics/health behaviours, the relationship between CMLE and the risk markers was attenuated for HDL-cholesterol, triglycerides, and HbA1c but remained significant for WC 0.70 (95% confidence interval (CI) 0.065– 1.30, p< 0.001) and SBP 1.48 (95% CI 0.48– 2.47 p< 0.001).Conclusion: There was a positive association between lower CMLE and the risk of MetS using the NCDS data. Lifestyle characteristics may be influential determinants of MetS risk in mid-adulthood.Keywords: maternal education, metabolic syndrome, risk markers, biomedical survey, NCDS datahttps://www.dovepress.com/childhood-maternal-school-leaving-age-level-of-education-and-risk-mark-peer-reviewed-article-DMSOmaternal educationmetabolic syndromerisk markersbiomedical surveyncds data |
| spellingShingle | Iwundu C Pang D Pappas Y Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort Diabetes, Metabolic Syndrome and Obesity maternal education metabolic syndrome risk markers biomedical survey ncds data |
| title | Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort |
| title_full | Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort |
| title_fullStr | Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort |
| title_full_unstemmed | Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort |
| title_short | Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort |
| title_sort | childhood maternal school leaving age level of education and risk markers of metabolic syndrome in mid adulthood results from the 1958 british birth cohort |
| topic | maternal education metabolic syndrome risk markers biomedical survey ncds data |
| url | https://www.dovepress.com/childhood-maternal-school-leaving-age-level-of-education-and-risk-mark-peer-reviewed-article-DMSO |
| work_keys_str_mv | AT iwunduc childhoodmaternalschoolleavingagelevelofeducationandriskmarkersofmetabolicsyndromeinmidadulthoodresultsfromthe1958britishbirthcohort AT pangd childhoodmaternalschoolleavingagelevelofeducationandriskmarkersofmetabolicsyndromeinmidadulthoodresultsfromthe1958britishbirthcohort AT pappasy childhoodmaternalschoolleavingagelevelofeducationandriskmarkersofmetabolicsyndromeinmidadulthoodresultsfromthe1958britishbirthcohort |