Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neuron...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/38588 |
| _version_ | 1811180539028176896 |
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| author | Daniel B Dorman Joanna Jędrzejewska-Szmek Kim T Blackwell |
| author_facet | Daniel B Dorman Joanna Jędrzejewska-Szmek Kim T Blackwell |
| author_sort | Daniel B Dorman |
| collection | DOAJ |
| description | Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium. We demonstrate that coordinated excitatory synaptic inputs evoke enhanced calcium elevation specific to stimulated spines, with lower but physiologically relevant calcium elevation in nearby non-stimulated spines. Results further show a novel and important function of inhibition—to enhance the difference in calcium between stimulated and non-stimulated spines. These findings suggest that spine calcium dynamics encode synaptic input patterns and may serve as a signal for both stimulus-specific potentiation and heterosynaptic depression, maintaining balanced activity in a dendritic branch while inducing pattern-specific plasticity. |
| first_indexed | 2024-04-11T09:04:48Z |
| format | Article |
| id | doaj.art-5ec4f40676164a79909872871e9b1844 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:04:48Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5ec4f40676164a79909872871e9b18442022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.38588Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained modelDaniel B Dorman0https://orcid.org/0000-0001-7006-4593Joanna Jędrzejewska-Szmek1https://orcid.org/0000-0002-2336-0848Kim T Blackwell2https://orcid.org/0000-0003-4711-2344Interdisciplinary Program in Neuroscience, George Mason University, Fairfax, United StatesKrasnow Institute for Advanced Study, George Mason University, Fairfax, United StatesInterdisciplinary Program in Neuroscience, Bioengineering Department, Krasnow Institute for Advanced Study, George Mason University, Fairfax, United StatesSynaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium. We demonstrate that coordinated excitatory synaptic inputs evoke enhanced calcium elevation specific to stimulated spines, with lower but physiologically relevant calcium elevation in nearby non-stimulated spines. Results further show a novel and important function of inhibition—to enhance the difference in calcium between stimulated and non-stimulated spines. These findings suggest that spine calcium dynamics encode synaptic input patterns and may serve as a signal for both stimulus-specific potentiation and heterosynaptic depression, maintaining balanced activity in a dendritic branch while inducing pattern-specific plasticity.https://elifesciences.org/articles/38588striatumdendritic integrationspine calciumplasticitycomputational model |
| spellingShingle | Daniel B Dorman Joanna Jędrzejewska-Szmek Kim T Blackwell Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model eLife striatum dendritic integration spine calcium plasticity computational model |
| title | Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model |
| title_full | Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model |
| title_fullStr | Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model |
| title_full_unstemmed | Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model |
| title_short | Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model |
| title_sort | inhibition enhances spatially specific calcium encoding of synaptic input patterns in a biologically constrained model |
| topic | striatum dendritic integration spine calcium plasticity computational model |
| url | https://elifesciences.org/articles/38588 |
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