Evaluating the impact of universal Lynch syndrome screening in a publicly funded healthcare system

Evaluating the impact of universal Lynch syndrome screening in a publicly funded healthcare system

Abstract Purpose Referrals for Lynch syndrome (LS) assessment have traditionally been based on personal and family medical history. The introduction of universal screening practices has allowed for referrals based on immunohistochemistry tests for mismatch repair (MMR) protein expression. This study...

Full description

Bibliographic Details
Main Authors:	Petra W. C. Lee, Angela C. Bedard, Setareh Samimi, Vivienne K. Beard, Quan Hong, James E. J. Bedard, Blake Gilks, David F. Schaeffer, Robert Wolber, Janice S. Kwon, Howard J. Lim, Sophie Sun, Kasmintan A. Schrader
Format:	Article
Language:	English
Published:	Wiley 2020-09-01
Series:	Cancer Medicine
Subjects:	colorectal cancer endometrial cancer DNA mismatch repair genetic testing immunohistochemistry Lynch syndrome
Online Access:	https://doi.org/10.1002/cam4.3279

Similar Items

Discordant immunohistochemistry in an unusual MLH1 gene variant in a case of Lynch syndrome
by: Prerana Nagabhushana, et al.
Published: (2021-08-01)

Lynch Syndrome and Gynecologic Tumors: Incidence, Prophylaxis, and Management of Patients with Cancer
by: Ilaria Capasso, et al.
Published: (2023-02-01)

Recent advances in Lynch syndrome
by: Xi Li, et al.
Published: (2021-06-01)

Advances in the Study of Lynch Syndrome Associated Endometrial Cancer
by: LIU Xiao, et al.
Published: (2023-01-01)

Gynecological Cancers in Lynch Syndrome: A Comparison of the Histological Features with Sporadic Cases of the General Population
by: Valentina Elisabetta Bounous, et al.
Published: (2022-06-01)

Fertility-sparing treatment for endometrial cancer and atypical endometrial hyperplasia in patients with Lynch Syndrome: Molecular diagnosis after immunohistochemistry of MMR proteins
by: Ursula Catena, et al.
Published: (2022-08-01)

What is currently known about endometrial cancer in Lynch syndrome? - review
by: Agnieszka Kwiatkowska, et al.
Published: (2019-09-01)

What is currently known about endometrial cancer in Lynch syndrome? - review
by: Agnieszka Kwiatkowska, et al.
Published: (2019-09-01)

An Update on Immune Checkpoint Therapy for the Treatment of Lynch Syndrome
by: Therkildsen C, et al.
Published: (2021-05-01)

Heterogeneity in the psychosocial and behavioral responses associated with a diagnosis of suspected Lynch syndrome in women with endometrial cancer
by: Sowmya Jonnagadla, et al.
Published: (2022-07-01)

The Prevalence and Molecular Landscape of Lynch Syndrome in the Affected and General Population
by: Laura Roht, et al.
Published: (2023-07-01)

Screening of Lynch syndrome in endometrial cancer in Iranian population with mismatch repair protein by immunohistochemistry
by: Somayyeh Noei Teymoordash, et al.
Published: (2022-09-01)

Lynch Syndrome Identification in Saudi Cohort of Endometrial Cancer Patients Screened by Universal Approach
by: Rong Bu, et al.
Published: (2022-10-01)

Comparison of Molecular, Clinicopathological, and Pedigree Differences Between Lynch-Like and Lynch Syndromes
by: Yun Xu, et al.
Published: (2020-08-01)

Gynecological Surveillance and Surgery Outcomes in Dutch Lynch Syndrome Carriers
by: Ellis L. Eikenboom, et al.
Published: (2021-01-01)

A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome
by: Romy Walker, et al.
Published: (2023-04-01)

A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification
by: Alessia Tognetto, et al.
Published: (2017-09-01)

Lynch-like Syndrome: Potential Mechanisms and Management
by: Alejandro Martínez-Roca, et al.
Published: (2022-02-01)

Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China
by: Xiaopei Chao, et al.
Published: (2019-07-01)

Feasibility of endometrial sampling by vaginal tampons in women with Lynch syndrome
by: Jorien M. Woolderink, et al.
Published: (2020-03-01)

Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors
by: Maria Rasmussen, et al.
Published: (2023-04-01)

Identification of novel Lynch syndrome mutations in Chinese patients with endometriod endometrial cancer
by: Caixia Ren, et al.
Published: (2020-05-01)

PMS2-associated Lynch syndrome: Past, present and future
by: Katarina D. Andini, et al.
Published: (2023-02-01)

Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database
by: Mev Dominguez-Valentin, et al.
Published: (2020-07-01)

Germline MLH1 and MSH6 mutations from two Lynch syndrome families identified in a patient with early-onset of endometrial cancer: A case report
by: Yi-Ching Huang, et al.
Published: (2024-06-01)

Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model
by: Wietske Pieters, et al.
Published: (2022-12-01)

Real-World Data on Institutional Implementation of Screening for Mismatch Repair Deficiency and Lynch Syndrome in Endometrial Cancer Patients
by: Carmen Joder, et al.
Published: (2024-02-01)

Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies
by: Neil A. J. Ryan, et al.
Published: (2021-09-01)

Lynch Syndrome: From Carcinogenesis to Prevention Interventions
by: Donatella Gambini, et al.
Published: (2022-08-01)

Exceptional Response to Pembrolizumab for Treatment of Metastatic Chemorefractory Endometrial Carcinoma in a Patient with Lynch Syndrome: A Case Report
by: Samantha Batman, et al.
Published: (2023-04-01)

HNRNPCL1, PRAMEF1, CFAP74, and DFFB: Common Potential Biomarkers for Sporadic and Suspected Lynch Syndrome Endometrial Cancer
by: Gao Y, et al.
Published: (2020-11-01)

Comparison of suspected Lynch syndrome patients carrying BRCA and BRCA‐like variants with Lynch syndrome probands: Phenotypic characteristics and pedigree analyses
by: Yun Xu, et al.
Published: (2020-08-01)

The prevalence of lynch syndrome (DNA mismatch repair protein deficiency) in patients with primary localized prostate cancer using immunohistochemistry screening
by: Suguru Oka, et al.
Published: (2023-10-01)

Lynch syndrome: from detection to treatment
by: Madeleine H. Williams, et al.
Published: (2023-05-01)

Testing strategies for Lynch syndrome in people with endometrial cancer: systematic reviews and economic evaluation
by: Chris Stinton, et al.
Published: (2021-06-01)

Single-center study of Lynch syndrome screening in colorectal polyps
by: FangChao Zhu, et al.
Published: (2019-03-01)

A simplified two-marker immunohistochemistry strategy for Lynch syndrome screening in endometrial cancer patients
by: Ala Aiob, et al.
Published: (2023-11-01)

Tumor mutational signatures in sebaceous skin lesions from individuals with Lynch syndrome
by: Peter Georgeson, et al.
Published: (2019-07-01)

An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach
by: Giulia Dondi, et al.
Published: (2020-09-01)

Updates in gynecologic care for individuals with lynch syndrome
by: Kaylee A. Underkofler, et al.
Published: (2023-03-01)