Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives
Cerebral palsy (CP) is a heterogeneous group of non-progressive syndromes with lots of clinical variations due to the extent of brain damages and etiologies. CP is majorly defined by dystonia and spasticity. The treatment of acquired dystonia in CP is very difficult. Many pharmacological treatments...
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MDPI AG
2021-05-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/6/481 |
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| author | Gaëtan Poulen Emilie Chan-Seng Emily Sanrey Philippe Coubes |
| author_facet | Gaëtan Poulen Emilie Chan-Seng Emily Sanrey Philippe Coubes |
| author_sort | Gaëtan Poulen |
| collection | DOAJ |
| description | Cerebral palsy (CP) is a heterogeneous group of non-progressive syndromes with lots of clinical variations due to the extent of brain damages and etiologies. CP is majorly defined by dystonia and spasticity. The treatment of acquired dystonia in CP is very difficult. Many pharmacological treatments have been tried and surgical treatment consists of deep brain stimulation (continuous electrical neuromodulation) of internal globus pallidus (GPi). A peculiar cause of CP is neonatal encephalopathy due to an anoxic event in the perinatal period. Many studies showed an improvement of dystonia in CP patients with bilateral GPi DBS. However, it remains a variability in the range of 1% to 50%. Published case-series concerned mainly small population with a majority of adult patients. Selection of patients according to the clinical pattern, to the brain lesions observed on classical imaging and to DTI is the key of a high success rate of DBS in children with perinatal hypoxemic encephalopathy. Only a large retrospective study with a high number of patients in a homogeneous pediatric population with a long-term follow-up or a prospective multicenter trial investigation could answer with a high degree of certitude of the real interest of this therapeutic in children with hypoxemic perinatal encephalopathy. |
| first_indexed | 2024-03-10T11:03:23Z |
| format | Article |
| id | doaj.art-5ec9b829bfbe40b792d1057cbfc85220 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T11:03:23Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-5ec9b829bfbe40b792d1057cbfc852202023-11-21T21:21:38ZengMDPI AGLife2075-17292021-05-0111648110.3390/life11060481Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and PerspectivesGaëtan Poulen0Emilie Chan-Seng1Emily Sanrey2Philippe Coubes3Unité “Pathologies Cérébrales Résistantes”, Department of Neurosurgery, Montpellier University Hospital, 34295 Montpellier, FranceUnité “Pathologies Cérébrales Résistantes”, Department of Neurosurgery, Montpellier University Hospital, 34295 Montpellier, FranceUnité “Pathologies Cérébrales Résistantes”, Department of Neurosurgery, Montpellier University Hospital, 34295 Montpellier, FranceUnité “Pathologies Cérébrales Résistantes”, Department of Neurosurgery, Montpellier University Hospital, 34295 Montpellier, FranceCerebral palsy (CP) is a heterogeneous group of non-progressive syndromes with lots of clinical variations due to the extent of brain damages and etiologies. CP is majorly defined by dystonia and spasticity. The treatment of acquired dystonia in CP is very difficult. Many pharmacological treatments have been tried and surgical treatment consists of deep brain stimulation (continuous electrical neuromodulation) of internal globus pallidus (GPi). A peculiar cause of CP is neonatal encephalopathy due to an anoxic event in the perinatal period. Many studies showed an improvement of dystonia in CP patients with bilateral GPi DBS. However, it remains a variability in the range of 1% to 50%. Published case-series concerned mainly small population with a majority of adult patients. Selection of patients according to the clinical pattern, to the brain lesions observed on classical imaging and to DTI is the key of a high success rate of DBS in children with perinatal hypoxemic encephalopathy. Only a large retrospective study with a high number of patients in a homogeneous pediatric population with a long-term follow-up or a prospective multicenter trial investigation could answer with a high degree of certitude of the real interest of this therapeutic in children with hypoxemic perinatal encephalopathy.https://www.mdpi.com/2075-1729/11/6/481deep brain stimulationinternal globus pallidushypoxemicanoxicencephalopathy |
| spellingShingle | Gaëtan Poulen Emilie Chan-Seng Emily Sanrey Philippe Coubes Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives Life deep brain stimulation internal globus pallidus hypoxemic anoxic encephalopathy |
| title | Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives |
| title_full | Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives |
| title_fullStr | Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives |
| title_full_unstemmed | Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives |
| title_short | Deep Brain Stimulation and Hypoxemic Perinatal Encephalopathy: State of Art and Perspectives |
| title_sort | deep brain stimulation and hypoxemic perinatal encephalopathy state of art and perspectives |
| topic | deep brain stimulation internal globus pallidus hypoxemic anoxic encephalopathy |
| url | https://www.mdpi.com/2075-1729/11/6/481 |
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