<i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases
Probiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/12/2382 |
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| author | Raden Mohamad Rendy Ariezal Effendi Muhammad Anshory Handono Kalim Reiva Farah Dwiyana Oki Suwarsa Luba M. Pardo Tamar E. C. Nijsten Hok Bing Thio |
| author_facet | Raden Mohamad Rendy Ariezal Effendi Muhammad Anshory Handono Kalim Reiva Farah Dwiyana Oki Suwarsa Luba M. Pardo Tamar E. C. Nijsten Hok Bing Thio |
| author_sort | Raden Mohamad Rendy Ariezal Effendi |
| collection | DOAJ |
| description | Probiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD). <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) and <i>Faecalibacterium prausnitzii</i> (<i>F. prausnitzii</i>) are two different types of bacteria that play a significant part in this function. It has been established that <i>Akkermansia</i> and <i>Faecalibacterium</i> are abundant in normal populations and have protective benefits on digestive health while also enhancing the immune system, metabolism, and gut barrier of the host. They have the potential to be a therapeutic target in diseases connected to the microbiota, such as immunological disorders and cancer immunotherapy. There has not been a review of the anti-inflammatory effects of <i>Akkermansia</i> and <i>Faecalibacterium</i>, particularly in immunological diseases. In this review, we highlight the most recent scientific findings regarding <i>A. muciniphila</i> and <i>F. prausnitzii</i> as two significant gut microbiota for microbiome alterations and seek to provide cutting-edge insight in terms of microbiome-targeted therapies as promising preventive and therapeutic tools in immune-related diseases and cancer immunotherapy. |
| first_indexed | 2024-03-09T16:04:11Z |
| format | Article |
| id | doaj.art-5eca290363054c5ab6741aa22bf45529 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:04:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-5eca290363054c5ab6741aa22bf455292023-11-24T16:48:09ZengMDPI AGMicroorganisms2076-26072022-11-011012238210.3390/microorganisms10122382<i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related DiseasesRaden Mohamad Rendy Ariezal Effendi0Muhammad Anshory1Handono Kalim2Reiva Farah Dwiyana3Oki Suwarsa4Luba M. Pardo5Tamar E. C. Nijsten6Hok Bing Thio7Department of Dermatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Dermatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Malang 65145, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine Universitas Padjadjaran—Dr. Hasan Sadikin Hospital, Bandung 45363, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine Universitas Padjadjaran—Dr. Hasan Sadikin Hospital, Bandung 45363, IndonesiaDepartment of Dermatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Dermatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Dermatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The NetherlandsProbiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD). <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) and <i>Faecalibacterium prausnitzii</i> (<i>F. prausnitzii</i>) are two different types of bacteria that play a significant part in this function. It has been established that <i>Akkermansia</i> and <i>Faecalibacterium</i> are abundant in normal populations and have protective benefits on digestive health while also enhancing the immune system, metabolism, and gut barrier of the host. They have the potential to be a therapeutic target in diseases connected to the microbiota, such as immunological disorders and cancer immunotherapy. There has not been a review of the anti-inflammatory effects of <i>Akkermansia</i> and <i>Faecalibacterium</i>, particularly in immunological diseases. In this review, we highlight the most recent scientific findings regarding <i>A. muciniphila</i> and <i>F. prausnitzii</i> as two significant gut microbiota for microbiome alterations and seek to provide cutting-edge insight in terms of microbiome-targeted therapies as promising preventive and therapeutic tools in immune-related diseases and cancer immunotherapy.https://www.mdpi.com/2076-2607/10/12/2382<i>Akkermansia muciniphila</i>atopic dermatitis<i>Faecalibacterium prausnitzii</i>human immunodeficiency virusimmune-related diseasesimmunotherapy |
| spellingShingle | Raden Mohamad Rendy Ariezal Effendi Muhammad Anshory Handono Kalim Reiva Farah Dwiyana Oki Suwarsa Luba M. Pardo Tamar E. C. Nijsten Hok Bing Thio <i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases Microorganisms <i>Akkermansia muciniphila</i> atopic dermatitis <i>Faecalibacterium prausnitzii</i> human immunodeficiency virus immune-related diseases immunotherapy |
| title | <i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases |
| title_full | <i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases |
| title_fullStr | <i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases |
| title_full_unstemmed | <i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases |
| title_short | <i>Akkermansia muciniphila</i> and <i>Faecalibacterium prausnitzii</i> in Immune-Related Diseases |
| title_sort | i akkermansia muciniphila i and i faecalibacterium prausnitzii i in immune related diseases |
| topic | <i>Akkermansia muciniphila</i> atopic dermatitis <i>Faecalibacterium prausnitzii</i> human immunodeficiency virus immune-related diseases immunotherapy |
| url | https://www.mdpi.com/2076-2607/10/12/2382 |
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