Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging
The aim of our intra-individual comparison study was to investigate and compare the potential of radiomics analysis of contrast-enhanced mammography (CEM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast for the non-invasive assessment of tumor invasiveness, hormone r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/7/492 |
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| author | Maria Adele Marino Doris Leithner Janice Sung Daly Avendano Elizabeth A. Morris Katja Pinker Maxine S. Jochelson |
| author_facet | Maria Adele Marino Doris Leithner Janice Sung Daly Avendano Elizabeth A. Morris Katja Pinker Maxine S. Jochelson |
| author_sort | Maria Adele Marino |
| collection | DOAJ |
| description | The aim of our intra-individual comparison study was to investigate and compare the potential of radiomics analysis of contrast-enhanced mammography (CEM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast for the non-invasive assessment of tumor invasiveness, hormone receptor status, and tumor grade in patients with primary breast cancer. This retrospective study included 48 female patients with 49 biopsy-proven breast cancers who underwent pretreatment breast CEM and MRI. Radiomics analysis was performed by using MaZda software. Radiomics parameters were correlated with tumor histology (invasive vs. non-invasive), hormonal status (HR+ vs. HR−), and grading (low grade G1 + G2 vs. high grade G3). CEM radiomics analysis yielded classification accuracies of up to 92% for invasive vs. non-invasive breast cancers, 95.6% for HR+ vs. HR− breast cancers, and 77.8% for G1 + G2 vs. G3 invasive cancers. MRI radiomics analysis yielded classification accuracies of up to 90% for invasive vs. non-invasive breast cancers, 82.6% for HR+ vs. HR− breast cancers, and 77.8% for G1+G2 vs. G3 cancers. Preliminary results indicate a potential of both radiomics analysis of DCE-MRI and CEM for non-invasive assessment of tumor-invasiveness, hormone receptor status, and tumor grade. CEM may serve as an alternative to MRI if MRI is not available or contraindicated. |
| first_indexed | 2024-03-10T18:22:43Z |
| format | Article |
| id | doaj.art-5ecb52152b934823a3bb3071ba28c655 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T18:22:43Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5ecb52152b934823a3bb3071ba28c6552023-11-20T07:13:49ZengMDPI AGDiagnostics2075-44182020-07-0110749210.3390/diagnostics10070492Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance ImagingMaria Adele Marino0Doris Leithner1Janice Sung2Daly Avendano3Elizabeth A. Morris4Katja Pinker5Maxine S. Jochelson6Memorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, New York, NY 10065, USAThe aim of our intra-individual comparison study was to investigate and compare the potential of radiomics analysis of contrast-enhanced mammography (CEM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast for the non-invasive assessment of tumor invasiveness, hormone receptor status, and tumor grade in patients with primary breast cancer. This retrospective study included 48 female patients with 49 biopsy-proven breast cancers who underwent pretreatment breast CEM and MRI. Radiomics analysis was performed by using MaZda software. Radiomics parameters were correlated with tumor histology (invasive vs. non-invasive), hormonal status (HR+ vs. HR−), and grading (low grade G1 + G2 vs. high grade G3). CEM radiomics analysis yielded classification accuracies of up to 92% for invasive vs. non-invasive breast cancers, 95.6% for HR+ vs. HR− breast cancers, and 77.8% for G1 + G2 vs. G3 invasive cancers. MRI radiomics analysis yielded classification accuracies of up to 90% for invasive vs. non-invasive breast cancers, 82.6% for HR+ vs. HR− breast cancers, and 77.8% for G1+G2 vs. G3 cancers. Preliminary results indicate a potential of both radiomics analysis of DCE-MRI and CEM for non-invasive assessment of tumor-invasiveness, hormone receptor status, and tumor grade. CEM may serve as an alternative to MRI if MRI is not available or contraindicated.https://www.mdpi.com/2075-4418/10/7/492radiomicscontrast-enhanced mammographybreast cancertexture analysisprognosisdiagnosis |
| spellingShingle | Maria Adele Marino Doris Leithner Janice Sung Daly Avendano Elizabeth A. Morris Katja Pinker Maxine S. Jochelson Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging Diagnostics radiomics contrast-enhanced mammography breast cancer texture analysis prognosis diagnosis |
| title | Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging |
| title_full | Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging |
| title_fullStr | Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging |
| title_full_unstemmed | Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging |
| title_short | Radiomics for Tumor Characterization in Breast Cancer Patients: A Feasibility Study Comparing Contrast-Enhanced Mammography and Magnetic Resonance Imaging |
| title_sort | radiomics for tumor characterization in breast cancer patients a feasibility study comparing contrast enhanced mammography and magnetic resonance imaging |
| topic | radiomics contrast-enhanced mammography breast cancer texture analysis prognosis diagnosis |
| url | https://www.mdpi.com/2075-4418/10/7/492 |
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