Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feeder...
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Bibliographic Details
| Main Authors: |
Renpeng Guo,
Xiaoying Ye,
Jiao Yang,
Zhongcheng Zhou,
Chenglei Tian,
Hua Wang,
Haiying Wang,
Haifeng Fu,
Chun Liu,
Ming Zeng,
Jun Yang,
Lin Liu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-05038-2
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