Protein S-palmitoylation in immunity
S-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S-palmitoylated immunity-associated proteins. H...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2021-03-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200411 |
| _version_ | 1818850432842203136 |
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| author | Tandrila Das Jacob S. Yount Howard C. Hang |
| author_facet | Tandrila Das Jacob S. Yount Howard C. Hang |
| author_sort | Tandrila Das |
| collection | DOAJ |
| description | S-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S-palmitoylated immunity-associated proteins. Here, we review S-palmitoylated immune receptors and effectors, and their dynamic regulation at cellular membranes to generate specific and balanced immune responses. We also highlight how this understanding can drive therapeutic advances to pharmacologically modulate immune responses. |
| first_indexed | 2024-12-19T06:49:03Z |
| format | Article |
| id | doaj.art-5ecd926d2daf4a5481c3d01a82903904 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-19T06:49:03Z |
| publishDate | 2021-03-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-5ecd926d2daf4a5481c3d01a829039042022-12-21T20:31:50ZengThe Royal SocietyOpen Biology2046-24412021-03-0111310.1098/rsob.200411200411Protein S-palmitoylation in immunityTandrila DasJacob S. YountHoward C. HangS-palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S-palmitoylated immunity-associated proteins. Here, we review S-palmitoylated immune receptors and effectors, and their dynamic regulation at cellular membranes to generate specific and balanced immune responses. We also highlight how this understanding can drive therapeutic advances to pharmacologically modulate immune responses.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200411s-palmitoylationadaptive immunityinnate immune receptorsinnate immune effectors |
| spellingShingle | Tandrila Das Jacob S. Yount Howard C. Hang Protein S-palmitoylation in immunity Open Biology s-palmitoylation adaptive immunity innate immune receptors innate immune effectors |
| title | Protein S-palmitoylation in immunity |
| title_full | Protein S-palmitoylation in immunity |
| title_fullStr | Protein S-palmitoylation in immunity |
| title_full_unstemmed | Protein S-palmitoylation in immunity |
| title_short | Protein S-palmitoylation in immunity |
| title_sort | protein s palmitoylation in immunity |
| topic | s-palmitoylation adaptive immunity innate immune receptors innate immune effectors |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200411 |
| work_keys_str_mv | AT tandriladas proteinspalmitoylationinimmunity AT jacobsyount proteinspalmitoylationinimmunity AT howardchang proteinspalmitoylationinimmunity |