Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents
The greatest threat to the health of the children exposed to radiation or born from irradiated parents after the accident at the Chernobyl NPP is the risk of developing stochastic radiation-induced pathology: genetic diseases, undifferentiated mental retardation, malignant neoplasms, etc. According...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2019-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/814 |
| _version_ | 1797875168981286912 |
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| author | L. S. Baleva A. E. Sipyagina |
| author_facet | L. S. Baleva A. E. Sipyagina |
| author_sort | L. S. Baleva |
| collection | DOAJ |
| description | The greatest threat to the health of the children exposed to radiation or born from irradiated parents after the accident at the Chernobyl NPP is the risk of developing stochastic radiation-induced pathology: genetic diseases, undifferentiated mental retardation, malignant neoplasms, etc. According to the provisions of international organizations (UNSCEAR, BEIR and ICRP), these effects can be caused by any dose, even a small one.Stochastic effects, which are currently associated with ionizing radiation, occur as mutations and then they are expressed to the final clinical manifestations (oncological, genetic pathology) as hidden genome damage. The article describes the complex of risk factors of developing radiation-induced diseases, namely, the phenomenon of genomic instability, the system of genomic DNA repair as a mechanism of anti-mutagenic protection, characteristic of gene expression of the TP53 gene network, immunological predictors of the risk of developing radiation-induced diseases for early diagnosis of the pathology and minimization of the effects of ionizing radiation. |
| first_indexed | 2024-04-10T01:43:20Z |
| format | Article |
| id | doaj.art-5ecf6507d656464eabc52619bc3903f3 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:43:20Z |
| publishDate | 2019-03-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-5ecf6507d656464eabc52619bc3903f32023-03-13T09:12:46ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282019-03-0164171410.21508/1027-4065-2019-64-1-7-14691Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parentsL. S. Baleva0A. E. Sipyagina1Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова Минздрава РоссииНаучно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова Минздрава РоссииThe greatest threat to the health of the children exposed to radiation or born from irradiated parents after the accident at the Chernobyl NPP is the risk of developing stochastic radiation-induced pathology: genetic diseases, undifferentiated mental retardation, malignant neoplasms, etc. According to the provisions of international organizations (UNSCEAR, BEIR and ICRP), these effects can be caused by any dose, even a small one.Stochastic effects, which are currently associated with ionizing radiation, occur as mutations and then they are expressed to the final clinical manifestations (oncological, genetic pathology) as hidden genome damage. The article describes the complex of risk factors of developing radiation-induced diseases, namely, the phenomenon of genomic instability, the system of genomic DNA repair as a mechanism of anti-mutagenic protection, characteristic of gene expression of the TP53 gene network, immunological predictors of the risk of developing radiation-induced diseases for early diagnosis of the pathology and minimization of the effects of ionizing radiation.https://www.ped-perinatology.ru/jour/article/view/814детиионизирующая радиациярадиационно-индуцированные стохастические заболеваниямедико-биологические предикторы риска |
| spellingShingle | L. S. Baleva A. E. Sipyagina Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents Rossijskij Vestnik Perinatologii i Pediatrii дети ионизирующая радиация радиационно-индуцированные стохастические заболевания медико-биологические предикторы риска |
| title | Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents |
| title_full | Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents |
| title_fullStr | Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents |
| title_full_unstemmed | Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents |
| title_short | Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents |
| title_sort | urgent problem of our time the risk of developing radiation induced stochastic diseases in the generations of children from irradiated parents |
| topic | дети ионизирующая радиация радиационно-индуцированные стохастические заболевания медико-биологические предикторы риска |
| url | https://www.ped-perinatology.ru/jour/article/view/814 |
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