Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma
Background/Aim. Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity. One of the numerous regulatory proteins is Ki-67 expressed in all prolife...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2007-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500705325J.pdf |
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| author | Janković-Veličković Ljubinka Đorđević Biljana Rančić Gorana Marjanović Goran |
| author_facet | Janković-Veličković Ljubinka Đorđević Biljana Rančić Gorana Marjanović Goran |
| author_sort | Janković-Veličković Ljubinka |
| collection | DOAJ |
| description | Background/Aim. Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity. One of the numerous regulatory proteins is Ki-67 expressed in all proliferating cells. Index Ki-67 is considered to have prognostic significance. The aim of the study was to compare the level of proliferation in hyperplastic epithelium, prostatic carcinoma (Gleason score > 6) and PINHG. Methods. Micromorphological examination was done in 85 patients. Pathohistological analysis was performed on standard histologic specimens with the estimation of Gleason score and the presence of PINHG in its surroundings. Nuclear proliferative activity was analyzed immunohistochemically in 19 cases, using a monoclonal anti-Ki-67 antibody. Results. PINHG was found in prostatic carcinoma surrounding in 30% of the patients. In hyperplastic epithelia Ki-67 proliferative activity was 1,08, in PINHG 2,25 (p < 0,05), while in prostatic cancer, Ki-67 index was 17,64. Proliferative activity in prostatic carcinoma was significantly higher than in PINHG (p < 0,001) and hyperplasia (p < 0,001). Conclusion. This study confirmed that high grade PIN lesion predominately appears in the surrounding of poor or moderately differentiated prostate carcinoma, and that it represents progressive disorder of proliferation in preneoplastic and neoplastic prostatic epithelium. . |
| first_indexed | 2024-12-13T05:47:22Z |
| format | Article |
| id | doaj.art-5ed0277fbf3b4a46a279f2396282e203 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-13T05:47:22Z |
| publishDate | 2007-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-5ed0277fbf3b4a46a279f2396282e2032022-12-21T23:57:38ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502007-01-0164532533010.2298/VSP0705325JExpression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinomaJanković-Veličković LjubinkaĐorđević BiljanaRančić GoranaMarjanović GoranBackground/Aim. Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity. One of the numerous regulatory proteins is Ki-67 expressed in all proliferating cells. Index Ki-67 is considered to have prognostic significance. The aim of the study was to compare the level of proliferation in hyperplastic epithelium, prostatic carcinoma (Gleason score > 6) and PINHG. Methods. Micromorphological examination was done in 85 patients. Pathohistological analysis was performed on standard histologic specimens with the estimation of Gleason score and the presence of PINHG in its surroundings. Nuclear proliferative activity was analyzed immunohistochemically in 19 cases, using a monoclonal anti-Ki-67 antibody. Results. PINHG was found in prostatic carcinoma surrounding in 30% of the patients. In hyperplastic epithelia Ki-67 proliferative activity was 1,08, in PINHG 2,25 (p < 0,05), while in prostatic cancer, Ki-67 index was 17,64. Proliferative activity in prostatic carcinoma was significantly higher than in PINHG (p < 0,001) and hyperplasia (p < 0,001). Conclusion. This study confirmed that high grade PIN lesion predominately appears in the surrounding of poor or moderately differentiated prostate carcinoma, and that it represents progressive disorder of proliferation in preneoplastic and neoplastic prostatic epithelium. .http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500705325J.pdfprostatic neoplasmsprecancerous conditionsgene expressionKi-67 antigenhistologyimmunohistochemistry |
| spellingShingle | Janković-Veličković Ljubinka Đorđević Biljana Rančić Gorana Marjanović Goran Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma Vojnosanitetski Pregled prostatic neoplasms precancerous conditions gene expression Ki-67 antigen histology immunohistochemistry |
| title | Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma |
| title_full | Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma |
| title_fullStr | Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma |
| title_full_unstemmed | Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma |
| title_short | Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma |
| title_sort | expression of nuclear ki 67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma |
| topic | prostatic neoplasms precancerous conditions gene expression Ki-67 antigen histology immunohistochemistry |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500705325J.pdf |
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