The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS

The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating noncommunicable disease brandishing an enormous worldwide disease burden with some evidence of inherited genetic risk. Absence of measurable changes in patients’ standard blood work has necessitated ad hoc sympto...

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Bibliographic Details
Main Authors: Alex A. Kashi, Ronald W. Davis, Robert D. Phair
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Diagnostics
Subjects:
tryptophan metabolism
indoleamine-2,3-dioxygenase
bistability
kynurenine pathway
substrate inhibition
myalgic encephalomyelitis
chronic fatigue syndrome
mathematical model
critical point
Online Access:https://www.mdpi.com/2075-4418/9/3/82

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