Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics
Tubo-ovarian cancer is the most lethal gynaecological cancer. More than 75% of patients are diagnosed at an advanced stage, which is associated with poorer overall survival. Symptoms at presentation are vague and non-specific, contributing to late diagnosis. Multimodal risk models have improved the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/21/3331 |
| _version_ | 1797632062763565056 |
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| author | Mark R. Brincat Ana Rita Mira Alexandra Lawrence |
| author_facet | Mark R. Brincat Ana Rita Mira Alexandra Lawrence |
| author_sort | Mark R. Brincat |
| collection | DOAJ |
| description | Tubo-ovarian cancer is the most lethal gynaecological cancer. More than 75% of patients are diagnosed at an advanced stage, which is associated with poorer overall survival. Symptoms at presentation are vague and non-specific, contributing to late diagnosis. Multimodal risk models have improved the diagnostic accuracy of adnexal mass assessment based on patient risk factors, coupled with findings on imaging and serum-based biomarker tests. Newly developed ultrasonographic assessment algorithms have standardised documentation and enable stratification of care between local hospitals and cancer centres. So far, no screening test has proven to reduce ovarian cancer mortality in the general population. This review is an update on the evidence behind ovarian cancer diagnostic strategies. |
| first_indexed | 2024-03-11T11:31:38Z |
| format | Article |
| id | doaj.art-5ed2299ab4b145e58e69669e675cac22 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T11:31:38Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5ed2299ab4b145e58e69669e675cac222023-11-10T15:01:00ZengMDPI AGDiagnostics2075-44182023-10-011321333110.3390/diagnostics13213331Current and Emerging Strategies for Tubo-Ovarian Cancer DiagnosticsMark R. Brincat0Ana Rita Mira1Alexandra Lawrence2Department of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UKDepartment of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UKDepartment of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UKTubo-ovarian cancer is the most lethal gynaecological cancer. More than 75% of patients are diagnosed at an advanced stage, which is associated with poorer overall survival. Symptoms at presentation are vague and non-specific, contributing to late diagnosis. Multimodal risk models have improved the diagnostic accuracy of adnexal mass assessment based on patient risk factors, coupled with findings on imaging and serum-based biomarker tests. Newly developed ultrasonographic assessment algorithms have standardised documentation and enable stratification of care between local hospitals and cancer centres. So far, no screening test has proven to reduce ovarian cancer mortality in the general population. This review is an update on the evidence behind ovarian cancer diagnostic strategies.https://www.mdpi.com/2075-4418/13/21/3331ovarian cancerscreeningdiagnosisbiomarkersimaging |
| spellingShingle | Mark R. Brincat Ana Rita Mira Alexandra Lawrence Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics Diagnostics ovarian cancer screening diagnosis biomarkers imaging |
| title | Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics |
| title_full | Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics |
| title_fullStr | Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics |
| title_full_unstemmed | Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics |
| title_short | Current and Emerging Strategies for Tubo-Ovarian Cancer Diagnostics |
| title_sort | current and emerging strategies for tubo ovarian cancer diagnostics |
| topic | ovarian cancer screening diagnosis biomarkers imaging |
| url | https://www.mdpi.com/2075-4418/13/21/3331 |
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