Bioactive Peptides and Proteins from Centipede Venoms
Venoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms. Through long-term evolution, venomous animals have evolved highly specific and diversified peptides and proteins targeting key physiological ele...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/14/4423 |
| _version_ | 1797416726741123072 |
|---|---|
| author | Yalan Han Peter Muiruri Kamau Ren Lai Lei Luo |
| author_facet | Yalan Han Peter Muiruri Kamau Ren Lai Lei Luo |
| author_sort | Yalan Han |
| collection | DOAJ |
| description | Venoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms. Through long-term evolution, venomous animals have evolved highly specific and diversified peptides and proteins targeting key physiological elements, including the nervous, blood, and muscular systems. Centipedes are typical venomous arthropods that rely on their toxins primarily for predation and defense. Although centipede bites are frequently reported, the composition and effect of centipede venoms are far from known. With the development of molecular biology and structural biology, the research on centipede venoms, especially peptides and proteins, has been deepened. Therefore, we summarize partial progress on the exploration of the bioactive peptides and proteins in centipede venoms and their potential value in pharmacological research and new drug development. |
| first_indexed | 2024-03-09T06:08:19Z |
| format | Article |
| id | doaj.art-5ed43722012849b7a06e529e252dc7bf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T06:08:19Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5ed43722012849b7a06e529e252dc7bf2023-12-03T12:01:08ZengMDPI AGMolecules1420-30492022-07-012714442310.3390/molecules27144423Bioactive Peptides and Proteins from Centipede VenomsYalan Han0Peter Muiruri Kamau1Ren Lai2Lei Luo3Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, ChinaVenoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms. Through long-term evolution, venomous animals have evolved highly specific and diversified peptides and proteins targeting key physiological elements, including the nervous, blood, and muscular systems. Centipedes are typical venomous arthropods that rely on their toxins primarily for predation and defense. Although centipede bites are frequently reported, the composition and effect of centipede venoms are far from known. With the development of molecular biology and structural biology, the research on centipede venoms, especially peptides and proteins, has been deepened. Therefore, we summarize partial progress on the exploration of the bioactive peptides and proteins in centipede venoms and their potential value in pharmacological research and new drug development.https://www.mdpi.com/1420-3049/27/14/4423venomcentipedepeptideproteindrug development |
| spellingShingle | Yalan Han Peter Muiruri Kamau Ren Lai Lei Luo Bioactive Peptides and Proteins from Centipede Venoms Molecules venom centipede peptide protein drug development |
| title | Bioactive Peptides and Proteins from Centipede Venoms |
| title_full | Bioactive Peptides and Proteins from Centipede Venoms |
| title_fullStr | Bioactive Peptides and Proteins from Centipede Venoms |
| title_full_unstemmed | Bioactive Peptides and Proteins from Centipede Venoms |
| title_short | Bioactive Peptides and Proteins from Centipede Venoms |
| title_sort | bioactive peptides and proteins from centipede venoms |
| topic | venom centipede peptide protein drug development |
| url | https://www.mdpi.com/1420-3049/27/14/4423 |
| work_keys_str_mv | AT yalanhan bioactivepeptidesandproteinsfromcentipedevenoms AT petermuirurikamau bioactivepeptidesandproteinsfromcentipedevenoms AT renlai bioactivepeptidesandproteinsfromcentipedevenoms AT leiluo bioactivepeptidesandproteinsfromcentipedevenoms |