Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice
Summary: Plasticity of thalamocortical (TC) synapses is robust during early development and becomes limited in the adult brain. We previously reported that a short duration of deafening strengthens TC synapses in the primary visual cortex (V1) of adult mice. Here, we demonstrate that deafening resto...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-09-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718313767 |
| _version_ | 1819048005246910464 |
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| author | Gabriela Rodríguez Darpan Chakraborty Katrina M. Schrode Rinki Saha Isabel Uribe Amanda M. Lauer Hey-Kyoung Lee |
| author_facet | Gabriela Rodríguez Darpan Chakraborty Katrina M. Schrode Rinki Saha Isabel Uribe Amanda M. Lauer Hey-Kyoung Lee |
| author_sort | Gabriela Rodríguez |
| collection | DOAJ |
| description | Summary: Plasticity of thalamocortical (TC) synapses is robust during early development and becomes limited in the adult brain. We previously reported that a short duration of deafening strengthens TC synapses in the primary visual cortex (V1) of adult mice. Here, we demonstrate that deafening restores NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of TC synapses onto principal neurons in V1 layer 4 (L4), which is accompanied by an increase in NMDAR function. In contrast, deafening did not recover long-term depression (LTD) at TC synapses. Potentiation of TC synapses by deafening is absent in parvalbumin-positive (PV+) interneurons, resulting in an increase in feedforward excitation to inhibition (E/I) ratio. Furthermore, we found that a brief duration of deafening adult mice recovers rapid ocular dominance plasticity (ODP) mainly by accelerating potentiation of the open-eye responses. Our results suggest that cross-modal sensory deprivation promotes adult cortical plasticity by specifically recovering TC-LTP and increasing the E/I ratio. : Plasticity of thalamocortical (TC) synapses is limited in adults. Rodríguez et al. demonstrate that a brief period of deafening adults recovers LTP at TC synapses in visual cortex and accelerates ocular dominance plasticity. These results suggest that cross-modal sensory deprivation may be an effective way to promote adult cortical plasticity. Keywords: cross-modal plasticity, thalamocortical LTP, visual cortex, adult cortical plasticity, E/I ratio, NMDA receptor function |
| first_indexed | 2024-12-21T11:09:22Z |
| format | Article |
| id | doaj.art-5ed4f75f279f4299a7efa9cab7f2cb7f |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T11:09:22Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-5ed4f75f279f4299a7efa9cab7f2cb7f2022-12-21T19:06:07ZengElsevierCell Reports2211-12472018-09-01241334333440.e4Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult MiceGabriela Rodríguez0Darpan Chakraborty1Katrina M. Schrode2Rinki Saha3Isabel Uribe4Amanda M. Lauer5Hey-Kyoung Lee6Mind/Brain Institute, Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall, Baltimore, MD 21218, USA; Cellular Molecular Developmental Biology and Biophysics Program, Johns Hopkins University, Mudd Hall, 3400 N. Charles Street, Baltimore, MD 21218, USAMind/Brain Institute, Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall, Baltimore, MD 21218, USADepartment of Otolaryngology–Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins School of Medicine, 720 Rutland Ave., Traylor Building, Baltimore, MD 21205, USAMind/Brain Institute, Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall, Baltimore, MD 21218, USAMind/Brain Institute, Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall, Baltimore, MD 21218, USADepartment of Otolaryngology–Head and Neck Surgery and Center for Hearing and Balance, Johns Hopkins School of Medicine, 720 Rutland Ave., Traylor Building, Baltimore, MD 21205, USAMind/Brain Institute, Department of Neuroscience, Johns Hopkins University, 3400 N. Charles Street, Dunning Hall, Baltimore, MD 21218, USA; Cellular Molecular Developmental Biology and Biophysics Program, Johns Hopkins University, Mudd Hall, 3400 N. Charles Street, Baltimore, MD 21218, USA; Corresponding authorSummary: Plasticity of thalamocortical (TC) synapses is robust during early development and becomes limited in the adult brain. We previously reported that a short duration of deafening strengthens TC synapses in the primary visual cortex (V1) of adult mice. Here, we demonstrate that deafening restores NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of TC synapses onto principal neurons in V1 layer 4 (L4), which is accompanied by an increase in NMDAR function. In contrast, deafening did not recover long-term depression (LTD) at TC synapses. Potentiation of TC synapses by deafening is absent in parvalbumin-positive (PV+) interneurons, resulting in an increase in feedforward excitation to inhibition (E/I) ratio. Furthermore, we found that a brief duration of deafening adult mice recovers rapid ocular dominance plasticity (ODP) mainly by accelerating potentiation of the open-eye responses. Our results suggest that cross-modal sensory deprivation promotes adult cortical plasticity by specifically recovering TC-LTP and increasing the E/I ratio. : Plasticity of thalamocortical (TC) synapses is limited in adults. Rodríguez et al. demonstrate that a brief period of deafening adults recovers LTP at TC synapses in visual cortex and accelerates ocular dominance plasticity. These results suggest that cross-modal sensory deprivation may be an effective way to promote adult cortical plasticity. Keywords: cross-modal plasticity, thalamocortical LTP, visual cortex, adult cortical plasticity, E/I ratio, NMDA receptor functionhttp://www.sciencedirect.com/science/article/pii/S2211124718313767 |
| spellingShingle | Gabriela Rodríguez Darpan Chakraborty Katrina M. Schrode Rinki Saha Isabel Uribe Amanda M. Lauer Hey-Kyoung Lee Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice Cell Reports |
| title | Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice |
| title_full | Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice |
| title_fullStr | Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice |
| title_full_unstemmed | Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice |
| title_short | Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice |
| title_sort | cross modal reinstatement of thalamocortical plasticity accelerates ocular dominance plasticity in adult mice |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718313767 |
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