Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma
Juvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disorder with multifaceted clinical findings in different organ systems. Neuropsychiatric manifestations affect more than half of SLE patients, and there is increasing evidence that anorexia nervosa (AN), a feeding and eating disord...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/4/697 |
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| author | Maria G. Grammatikopoulou Vasiliki Syrmou Maria-Lydia Lioliopoulou Konstantinos Gkiouras Theodora Simopoulou Christina G. Katsiari Tonia Vassilakou Dimitrios P. Bogdanos |
| author_facet | Maria G. Grammatikopoulou Vasiliki Syrmou Maria-Lydia Lioliopoulou Konstantinos Gkiouras Theodora Simopoulou Christina G. Katsiari Tonia Vassilakou Dimitrios P. Bogdanos |
| author_sort | Maria G. Grammatikopoulou |
| collection | DOAJ |
| description | Juvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disorder with multifaceted clinical findings in different organ systems. Neuropsychiatric manifestations affect more than half of SLE patients, and there is increasing evidence that anorexia nervosa (AN), a feeding and eating disorder (FED) characterized by significantly reduced energy intake, is among them. Herein, a review of the literature on the potential association between jSLE and AN was performed. Reported clinical cases were identified, and putative pathophysiological mechanisms were sought that could potentially explain the observed relationship between these two pathological entities. Four reports of isolated cases and a case series including seven patients were identified. In this limited patient pool, the diagnosis of AN preceded that of SLE in the majority of cases, whereas in all cases both entities were diagnosed within a time span of two years. Many explanations for the observed relationships have been proposed. AN has been associated with the stress of chronic disease diagnosis; on the other hand, the chronic inflammation associated with AN may contribute to the development/appearance of SLE. Adverse childhood experiences, concentrations of leptin, shared autoantibodies, and genetic traits appear to be important factors in this well-established interplay. In essence, it seems important to increase clinician awareness of the concomitant development of AN and SLE and invite further research on the subject. |
| first_indexed | 2024-03-11T05:08:00Z |
| format | Article |
| id | doaj.art-5ed502a5795f422795ddcfb4f721910a |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T05:08:00Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-5ed502a5795f422795ddcfb4f721910a2023-11-17T18:46:26ZengMDPI AGChildren2227-90672023-04-0110469710.3390/children10040697Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality DilemmaMaria G. Grammatikopoulou0Vasiliki Syrmou1Maria-Lydia Lioliopoulou2Konstantinos Gkiouras3Theodora Simopoulou4Christina G. Katsiari5Tonia Vassilakou6Dimitrios P. Bogdanos7Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceUnit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceUnit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceUnit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceUnit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceUnit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceDepartment of Public Health Policy, School of Public Health, University of West Attica, 196 Alexandras Avenue, GR-11521 Athens, GreeceUnit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41110 Larissa, GreeceJuvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disorder with multifaceted clinical findings in different organ systems. Neuropsychiatric manifestations affect more than half of SLE patients, and there is increasing evidence that anorexia nervosa (AN), a feeding and eating disorder (FED) characterized by significantly reduced energy intake, is among them. Herein, a review of the literature on the potential association between jSLE and AN was performed. Reported clinical cases were identified, and putative pathophysiological mechanisms were sought that could potentially explain the observed relationship between these two pathological entities. Four reports of isolated cases and a case series including seven patients were identified. In this limited patient pool, the diagnosis of AN preceded that of SLE in the majority of cases, whereas in all cases both entities were diagnosed within a time span of two years. Many explanations for the observed relationships have been proposed. AN has been associated with the stress of chronic disease diagnosis; on the other hand, the chronic inflammation associated with AN may contribute to the development/appearance of SLE. Adverse childhood experiences, concentrations of leptin, shared autoantibodies, and genetic traits appear to be important factors in this well-established interplay. In essence, it seems important to increase clinician awareness of the concomitant development of AN and SLE and invite further research on the subject.https://www.mdpi.com/2227-9067/10/4/697neuropsychiatric lupusdepressionfeeding and eating disorderleptinmental healthweight loss |
| spellingShingle | Maria G. Grammatikopoulou Vasiliki Syrmou Maria-Lydia Lioliopoulou Konstantinos Gkiouras Theodora Simopoulou Christina G. Katsiari Tonia Vassilakou Dimitrios P. Bogdanos Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma Children neuropsychiatric lupus depression feeding and eating disorder leptin mental health weight loss |
| title | Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma |
| title_full | Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma |
| title_fullStr | Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma |
| title_full_unstemmed | Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma |
| title_short | Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma |
| title_sort | anorexia nervosa in juvenile systemic lupus erythematosus sle a causality dilemma |
| topic | neuropsychiatric lupus depression feeding and eating disorder leptin mental health weight loss |
| url | https://www.mdpi.com/2227-9067/10/4/697 |
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