The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer
Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with metastatic lesions extending beyond the ovary. Th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1275154/full |
| _version_ | 1797630674062016512 |
|---|---|
| author | Biqing Chen Liping Zhao Rulin Yang Tianmin Xu |
| author_facet | Biqing Chen Liping Zhao Rulin Yang Tianmin Xu |
| author_sort | Biqing Chen |
| collection | DOAJ |
| description | Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with metastatic lesions extending beyond the ovary. This presents a significant clinical challenge and imposes a substantial economic burden on both patients and society. Despite advancements in surgery, chemotherapy, and immunotherapy, the prognosis for most patients with ovarian cancer remains unsatisfactory. Therefore, the development of novel treatment strategies is imperative. Ferroptosis, a distinct form of regulated cell death, characterized by iron-dependent lipid peroxidation, differs from autophagy, apoptosis, and necrosis, and may hold promise as a novel cell death. Numerous studies have demonstrated the involvement of ferroptosis in various conventional signaling pathways and biological processes. Recent investigations have revealed the significant contribution of ferroptosis in the initiation, progression, and metastasis of diverse malignant tumors, including ovarian cancer. Moreover, ferroptosis exhibits a synergistic effect with chemotherapy, radiotherapy, and immunotherapy in restraining the proliferation of ovarian cancer cells. The aforementioned implies that ferroptosis holds considerable importance in the management of ovarian cancer and has the potential to serve as a novel therapeutic target. The present review provides a comprehensive overview of the salient features of ferroptosis, encompassing its underlying mechanisms and functional role in ovarian cancer, along with the associated signaling pathways and genes. Furthermore, the review highlights the prospective utility of ferroptosis in the treatment of ovarian cancer. |
| first_indexed | 2024-03-11T11:11:31Z |
| format | Article |
| id | doaj.art-5ed5dde1fe9f475fa6c86cbf80537bd2 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-11T11:11:31Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-5ed5dde1fe9f475fa6c86cbf80537bd22023-11-11T22:41:49ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-11-011410.3389/fgene.2023.12751541275154The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancerBiqing ChenLiping ZhaoRulin YangTianmin XuOvarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with metastatic lesions extending beyond the ovary. This presents a significant clinical challenge and imposes a substantial economic burden on both patients and society. Despite advancements in surgery, chemotherapy, and immunotherapy, the prognosis for most patients with ovarian cancer remains unsatisfactory. Therefore, the development of novel treatment strategies is imperative. Ferroptosis, a distinct form of regulated cell death, characterized by iron-dependent lipid peroxidation, differs from autophagy, apoptosis, and necrosis, and may hold promise as a novel cell death. Numerous studies have demonstrated the involvement of ferroptosis in various conventional signaling pathways and biological processes. Recent investigations have revealed the significant contribution of ferroptosis in the initiation, progression, and metastasis of diverse malignant tumors, including ovarian cancer. Moreover, ferroptosis exhibits a synergistic effect with chemotherapy, radiotherapy, and immunotherapy in restraining the proliferation of ovarian cancer cells. The aforementioned implies that ferroptosis holds considerable importance in the management of ovarian cancer and has the potential to serve as a novel therapeutic target. The present review provides a comprehensive overview of the salient features of ferroptosis, encompassing its underlying mechanisms and functional role in ovarian cancer, along with the associated signaling pathways and genes. Furthermore, the review highlights the prospective utility of ferroptosis in the treatment of ovarian cancer.https://www.frontiersin.org/articles/10.3389/fgene.2023.1275154/fullferroptosisovarian cancerferroptosis-related genesimmunotherapydrug tolerance |
| spellingShingle | Biqing Chen Liping Zhao Rulin Yang Tianmin Xu The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer Frontiers in Genetics ferroptosis ovarian cancer ferroptosis-related genes immunotherapy drug tolerance |
| title | The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer |
| title_full | The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer |
| title_fullStr | The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer |
| title_full_unstemmed | The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer |
| title_short | The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer |
| title_sort | recent advancements of ferroptosis in the diagnosis treatment and prognosis of ovarian cancer |
| topic | ferroptosis ovarian cancer ferroptosis-related genes immunotherapy drug tolerance |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1275154/full |
| work_keys_str_mv | AT biqingchen therecentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT lipingzhao therecentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT rulinyang therecentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT tianminxu therecentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT biqingchen recentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT lipingzhao recentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT rulinyang recentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer AT tianminxu recentadvancementsofferroptosisinthediagnosistreatmentandprognosisofovariancancer |