Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience
Background: Large epidemiological studies describing the trends in incidence rates and mortality of synchronous brain metastases (SBMs) are lacking. The study aimed to provide a comprehensive understanding of the changes in the incidence and mortality of SBMs over the previous ten years. Methods: Tr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/11/660 |
| _version_ | 1827646860636979200 |
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| author | Wenqiang Che Jie Liu Tengyue Fu Xiangyu Wang Jun Lyu |
| author_facet | Wenqiang Che Jie Liu Tengyue Fu Xiangyu Wang Jun Lyu |
| author_sort | Wenqiang Che |
| collection | DOAJ |
| description | Background: Large epidemiological studies describing the trends in incidence rates and mortality of synchronous brain metastases (SBMs) are lacking. The study aimed to provide a comprehensive understanding of the changes in the incidence and mortality of SBMs over the previous ten years. Methods: Trends in the incidence of solid malignancies outside of the CNS in patients with SBMs and incidence-based mortality rates were assessed using data from the Surveillance, Epidemiology, and End Results database. Joinpoint analyses were used to calculate annual percent changes (APCs) and 95% CIs. Results: Between 2010 and 2019, 66,655 patients, including 34,821 (52.24%) men and 31,834 (47.76%) women, were found to have SBMs, and 57,692 deaths occurred over this period. Lung cancer SBMs, melanoma SBMs, and breast cancer SBMs were ranked in the top three, having the highest age-standardized incidence rates. The incidence of SBMs decreased significantly with an APC of −0.6% from 2010 to 2019, while the APC was 1.2% for lung cancer SBMs, 2.5% for melanoma SBMs, and 0.6% for breast cancer SBMs. The SBM mortality first experienced a rapid increase (APC = 28.6%) from 2010 to 2012 and then showed a significant decline at an APC of −1.8% from 2012 to 2019. Lung cancer SBMs showed similar trends, while melanoma SBM and breast cancer SBM mortality increased continuously. Conclusions: SBMs incidence (2010–2019) and incidence-based mortality (2012–2019) declined significantly. These findings can advance our understanding of the prevalence of SBMs. |
| first_indexed | 2024-03-09T19:09:19Z |
| format | Article |
| id | doaj.art-5ed70e5628054696ba3413d848f015b9 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T19:09:19Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-5ed70e5628054696ba3413d848f015b92023-11-24T04:16:31ZengMDPI AGCurrent Oncology1198-00521718-77292022-11-0129118374838910.3390/curroncol29110660Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter ExperienceWenqiang Che0Jie Liu1Tengyue Fu2Xiangyu Wang3Jun Lyu4Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaBackground: Large epidemiological studies describing the trends in incidence rates and mortality of synchronous brain metastases (SBMs) are lacking. The study aimed to provide a comprehensive understanding of the changes in the incidence and mortality of SBMs over the previous ten years. Methods: Trends in the incidence of solid malignancies outside of the CNS in patients with SBMs and incidence-based mortality rates were assessed using data from the Surveillance, Epidemiology, and End Results database. Joinpoint analyses were used to calculate annual percent changes (APCs) and 95% CIs. Results: Between 2010 and 2019, 66,655 patients, including 34,821 (52.24%) men and 31,834 (47.76%) women, were found to have SBMs, and 57,692 deaths occurred over this period. Lung cancer SBMs, melanoma SBMs, and breast cancer SBMs were ranked in the top three, having the highest age-standardized incidence rates. The incidence of SBMs decreased significantly with an APC of −0.6% from 2010 to 2019, while the APC was 1.2% for lung cancer SBMs, 2.5% for melanoma SBMs, and 0.6% for breast cancer SBMs. The SBM mortality first experienced a rapid increase (APC = 28.6%) from 2010 to 2012 and then showed a significant decline at an APC of −1.8% from 2012 to 2019. Lung cancer SBMs showed similar trends, while melanoma SBM and breast cancer SBM mortality increased continuously. Conclusions: SBMs incidence (2010–2019) and incidence-based mortality (2012–2019) declined significantly. These findings can advance our understanding of the prevalence of SBMs.https://www.mdpi.com/1718-7729/29/11/660brain metastasestrendsincidencemortalitySEER |
| spellingShingle | Wenqiang Che Jie Liu Tengyue Fu Xiangyu Wang Jun Lyu Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience Current Oncology brain metastases trends incidence mortality SEER |
| title | Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience |
| title_full | Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience |
| title_fullStr | Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience |
| title_full_unstemmed | Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience |
| title_short | Recent Trends in Synchronous Brain Metastasis Incidence and Mortality in the United States: Ten-Year Multicenter Experience |
| title_sort | recent trends in synchronous brain metastasis incidence and mortality in the united states ten year multicenter experience |
| topic | brain metastases trends incidence mortality SEER |
| url | https://www.mdpi.com/1718-7729/29/11/660 |
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