Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers
Newborns and infants are more sensitive to harmful compounds such as bisphenols and their derivatives because of their not fully developed detoxification mechanism. Exposure to these substances can lead to developmental problems and health consequences in adulthood. Since disposable baby diapers are...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323008552 |
| _version_ | 1797744128306446336 |
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| author | Aneta Chabowska Natalia Jatkowska Paweł Kubica Justyna Płotka-Wasylka |
| author_facet | Aneta Chabowska Natalia Jatkowska Paweł Kubica Justyna Płotka-Wasylka |
| author_sort | Aneta Chabowska |
| collection | DOAJ |
| description | Newborns and infants are more sensitive to harmful compounds such as bisphenols and their derivatives because of their not fully developed detoxification mechanism. Exposure to these substances can lead to developmental problems and health consequences in adulthood. Since disposable baby diapers are used from the first days of life and remain in contact with the baby skin, it seems important to monitor the levels of endocrine disrupting chemicals (EDCs) in such products. Ultrasound assisted solvent microextraction of porous membrane-packed solid sample (UASE-PMSS) was used in sample preparation. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used at determination step. Bisphenol A was quantified with the highest frequency at 81 % of samples tested, ranging from 5.0 to 520 ng/g. BADGE·2HCl was also quantified in high concentrations (from 6.8 to 530 ng/g), but was found in only 15 % of the tested samples. The daily exposure dose (DED) of bisphenols was calculated. In addition health risk assessment was conducted using previous (4 µg/kg BW) and actual (0.2 ng/kg BW) values of tolerable daily intake (TDI) of bisphenol A recommended by European Food Safety Authority (EFSA). |
| first_indexed | 2024-03-12T15:05:18Z |
| format | Article |
| id | doaj.art-5ed7faa7d0314d08830272562a6d42f5 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-12T15:05:18Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-5ed7faa7d0314d08830272562a6d42f52023-08-13T04:52:09ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01262115351Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapersAneta Chabowska0Natalia Jatkowska1Paweł Kubica2Justyna Płotka-Wasylka3Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, PolandDepartment of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland; Corresponding author.Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, PolandDepartment of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland; BioTechMed Center, Research Centre, Gdańsk University of Technology, G. Narutowicza St. 11/12, 80-233 Gdańsk, Poland; Corresponding author at: Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland.Newborns and infants are more sensitive to harmful compounds such as bisphenols and their derivatives because of their not fully developed detoxification mechanism. Exposure to these substances can lead to developmental problems and health consequences in adulthood. Since disposable baby diapers are used from the first days of life and remain in contact with the baby skin, it seems important to monitor the levels of endocrine disrupting chemicals (EDCs) in such products. Ultrasound assisted solvent microextraction of porous membrane-packed solid sample (UASE-PMSS) was used in sample preparation. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used at determination step. Bisphenol A was quantified with the highest frequency at 81 % of samples tested, ranging from 5.0 to 520 ng/g. BADGE·2HCl was also quantified in high concentrations (from 6.8 to 530 ng/g), but was found in only 15 % of the tested samples. The daily exposure dose (DED) of bisphenols was calculated. In addition health risk assessment was conducted using previous (4 µg/kg BW) and actual (0.2 ng/kg BW) values of tolerable daily intake (TDI) of bisphenol A recommended by European Food Safety Authority (EFSA).http://www.sciencedirect.com/science/article/pii/S0147651323008552Disposable baby diapersSample preparationUASE-PMSS-UPLC-MS/MSBisphenolsChildren exposure |
| spellingShingle | Aneta Chabowska Natalia Jatkowska Paweł Kubica Justyna Płotka-Wasylka Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers Ecotoxicology and Environmental Safety Disposable baby diapers Sample preparation UASE-PMSS-UPLC-MS/MS Bisphenols Children exposure |
| title | Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers |
| title_full | Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers |
| title_fullStr | Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers |
| title_full_unstemmed | Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers |
| title_short | Exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers |
| title_sort | exposure scenario and risk assessment of infants and newborns to bisphenols and their derivatives from diapers |
| topic | Disposable baby diapers Sample preparation UASE-PMSS-UPLC-MS/MS Bisphenols Children exposure |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323008552 |
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