CD4+ T-cell priming as biomarker to study immune response to preventive vaccines
T-cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4+ T-cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key tar...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00421/full |
| _version_ | 1818364776457175040 |
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| author | Annalisa eCiabattini Elena ePettini Donata eMedaglini |
| author_facet | Annalisa eCiabattini Elena ePettini Donata eMedaglini |
| author_sort | Annalisa eCiabattini |
| collection | DOAJ |
| description | T-cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4+ T-cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major challenge in the study of in vivo T-cell priming is due to the low frequency of antigen-specific T cells. This review discusses the current knowledge on antigen-specific CD4+ T-cell priming in the context of vaccination, as well as the most advanced tools for the characterization of the in vivo T-cell priming and the opportunities offered by the application of systems biology. |
| first_indexed | 2024-12-13T22:09:45Z |
| format | Article |
| id | doaj.art-5ed87f39630a4477b08dc08bdd1db203 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T22:09:45Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5ed87f39630a4477b08dc08bdd1db2032022-12-21T23:29:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-12-01410.3389/fimmu.2013.0042169830CD4+ T-cell priming as biomarker to study immune response to preventive vaccinesAnnalisa eCiabattini0Elena ePettini1Donata eMedaglini2University of SienaUniversity of SienaUniversity of SienaT-cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4+ T-cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major challenge in the study of in vivo T-cell priming is due to the low frequency of antigen-specific T cells. This review discusses the current knowledge on antigen-specific CD4+ T-cell priming in the context of vaccination, as well as the most advanced tools for the characterization of the in vivo T-cell priming and the opportunities offered by the application of systems biology.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00421/fullAdoptive TransferVaccinationCD4+ T cellsmucosal immunityT-cell primingMHC class II tetramers |
| spellingShingle | Annalisa eCiabattini Elena ePettini Donata eMedaglini CD4+ T-cell priming as biomarker to study immune response to preventive vaccines Frontiers in Immunology Adoptive Transfer Vaccination CD4+ T cells mucosal immunity T-cell priming MHC class II tetramers |
| title | CD4+ T-cell priming as biomarker to study immune response to preventive vaccines |
| title_full | CD4+ T-cell priming as biomarker to study immune response to preventive vaccines |
| title_fullStr | CD4+ T-cell priming as biomarker to study immune response to preventive vaccines |
| title_full_unstemmed | CD4+ T-cell priming as biomarker to study immune response to preventive vaccines |
| title_short | CD4+ T-cell priming as biomarker to study immune response to preventive vaccines |
| title_sort | cd4 t cell priming as biomarker to study immune response to preventive vaccines |
| topic | Adoptive Transfer Vaccination CD4+ T cells mucosal immunity T-cell priming MHC class II tetramers |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00421/full |
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