Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study
Abstract Introduction We investigated the association of serum uric acid to high‐density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants. Methods In this cross‐sectional study, according to International Diabetes Federation criteri...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.446 |
| _version_ | 1827765037401374720 |
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| author | Rana Kolahi Ahari Amin Mansoori Toktam Sahranavard Monireh Sadat Miri Sara Feizi Habibollah Esmaily Majid Ghayour‐Mobarhan |
| author_facet | Rana Kolahi Ahari Amin Mansoori Toktam Sahranavard Monireh Sadat Miri Sara Feizi Habibollah Esmaily Majid Ghayour‐Mobarhan |
| author_sort | Rana Kolahi Ahari |
| collection | DOAJ |
| description | Abstract Introduction We investigated the association of serum uric acid to high‐density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants. Methods In this cross‐sectional study, according to International Diabetes Federation criteria, the cohort participants were divided into MetS (+) and MetS (−) groups. MetS (+) were classified into Group 1 (those with 3 MetS criteria), Group 2 (those with 4 MetS criteria) and Group 3 (those with 5 MetS criteria). UHR was compared among the groups. Results Data related to 9637 subjects including 3824 MetS (+) and 5813 MetS (−) were analysed. The mean UHR was significantly higher (p < .001) in the MetS (+) group compared with the MetS (−) group. UHR increased as the MetS severity increased (p < .001). ROC analysis revealed that UHR greater than 9.5% has 89.07% sensitivity and 77.03% specificity in differentiating MetS (−) from MetS (+) subjects. Conclusion Among MASHAD cohort study participants, a significant association between UHR and MetS was found. Furthermore, there is an increase in UHR as the severity of MetS increases. Registration number of MASHAD cohort study: 85134. |
| first_indexed | 2024-03-11T11:13:25Z |
| format | Article |
| id | doaj.art-5ed8a82fecd2482f88d810c87de14ba3 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-03-11T11:13:25Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-5ed8a82fecd2482f88d810c87de14ba32023-11-11T09:37:05ZengWileyEndocrinology, Diabetes & Metabolism2398-92382023-11-0166n/an/a10.1002/edm2.446Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale studyRana Kolahi Ahari0Amin Mansoori1Toktam Sahranavard2Monireh Sadat Miri3Sara Feizi4Habibollah Esmaily5Majid Ghayour‐Mobarhan6International UNESCO Center for Health‐Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences Mashhad IranInternational UNESCO Center for Health‐Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences Mashhad IranInternational UNESCO Center for Health‐Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences Mashhad IranDepartment of Biology, Faculty of Sciences, Mashhad Branch Islamic Azad University Mashhad IranDepartment of Biology, Faculty of Sciences, Mashhad Branch Islamic Azad University Mashhad IranDepartment of Biostatistics, School of Health Mashhad University of Medical Sciences Mashhad IranInternational UNESCO Center for Health‐Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences Mashhad IranAbstract Introduction We investigated the association of serum uric acid to high‐density lipoprotein ratio (UHR) with the presence and severity of metabolic syndrome (MetS) among MASHAD cohort participants. Methods In this cross‐sectional study, according to International Diabetes Federation criteria, the cohort participants were divided into MetS (+) and MetS (−) groups. MetS (+) were classified into Group 1 (those with 3 MetS criteria), Group 2 (those with 4 MetS criteria) and Group 3 (those with 5 MetS criteria). UHR was compared among the groups. Results Data related to 9637 subjects including 3824 MetS (+) and 5813 MetS (−) were analysed. The mean UHR was significantly higher (p < .001) in the MetS (+) group compared with the MetS (−) group. UHR increased as the MetS severity increased (p < .001). ROC analysis revealed that UHR greater than 9.5% has 89.07% sensitivity and 77.03% specificity in differentiating MetS (−) from MetS (+) subjects. Conclusion Among MASHAD cohort study participants, a significant association between UHR and MetS was found. Furthermore, there is an increase in UHR as the severity of MetS increases. Registration number of MASHAD cohort study: 85134.https://doi.org/10.1002/edm2.446high‐density lipoproteinmetabolic syndromeUHRuric acid |
| spellingShingle | Rana Kolahi Ahari Amin Mansoori Toktam Sahranavard Monireh Sadat Miri Sara Feizi Habibollah Esmaily Majid Ghayour‐Mobarhan Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study Endocrinology, Diabetes & Metabolism high‐density lipoprotein metabolic syndrome UHR uric acid |
| title | Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study |
| title_full | Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study |
| title_fullStr | Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study |
| title_full_unstemmed | Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study |
| title_short | Serum uric acid to high‐density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome: A large‐scale study |
| title_sort | serum uric acid to high density lipoprotein ratio as a novel indicator of inflammation is correlated with the presence and severity of metabolic syndrome a large scale study |
| topic | high‐density lipoprotein metabolic syndrome UHR uric acid |
| url | https://doi.org/10.1002/edm2.446 |
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