The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension
Abstract Pulmonary hypertension (PH) was a cardiovascular disease with high morbidity and mortality. PH was a chronic disease with complicated pathogenesis and uncontrollable factors. PH was divided into five groups according to its pathogenesis and clinical manifestations. Although the treatment an...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01373-6 |
| _version_ | 1797865536160268288 |
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| author | Yang Sun Shasha Liu Chen Chen Songwei Yang Gang Pei Meiyu Lin Ting Wang Junpeng Long Qian Yan Jiao Yao Yuting Lin Fan Yi Lei Meng Yong Tan Qidi Ai Naihong Chen Yantao Yang |
| author_facet | Yang Sun Shasha Liu Chen Chen Songwei Yang Gang Pei Meiyu Lin Ting Wang Junpeng Long Qian Yan Jiao Yao Yuting Lin Fan Yi Lei Meng Yong Tan Qidi Ai Naihong Chen Yantao Yang |
| author_sort | Yang Sun |
| collection | DOAJ |
| description | Abstract Pulmonary hypertension (PH) was a cardiovascular disease with high morbidity and mortality. PH was a chronic disease with complicated pathogenesis and uncontrollable factors. PH was divided into five groups according to its pathogenesis and clinical manifestations. Although the treatment and diagnosis of PH has made great progress in the past ten years. However, the diagnosis and prognosis of the PAH had a great contrast, which was not conducive to the diagnosis and treatment of PH. If not treated properly, it will lead to right ventricular failure or even death. Therefore, it was necessary to explore the pathogenesis of PH. The problem we urgently need to solve was to find and develop drugs for the treatment of PH. We reviewed the PH articles in the past 10 years or so as well as systematically summarized the recent advance. We summarized the latest research on the key regulatory factors (pyroptosis, apoptosis, necroptosis, ferroptosis, and endoplasmic reticulum stress) involved in PH. To provide theoretical basis and basis for finding new therapeutic targets and research directions of PH. |
| first_indexed | 2024-04-09T23:10:45Z |
| format | Article |
| id | doaj.art-5ed971af45b24002b9b1431b6e1c37d5 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-09T23:10:45Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-5ed971af45b24002b9b1431b6e1c37d52023-03-22T10:25:31ZengNature Publishing GroupCell Death Discovery2058-77162023-02-01911910.1038/s41420-023-01373-6The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertensionYang Sun0Shasha Liu1Chen Chen2Songwei Yang3Gang Pei4Meiyu Lin5Ting Wang6Junpeng Long7Qian Yan8Jiao Yao9Yuting Lin10Fan Yi11Lei Meng12Yong Tan13Qidi Ai14Naihong Chen15Yantao Yang16Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineDepartment of Pharmacy, Changsha Hospital for Matemal & Child Health CareDepartment of Pharmacy, The First Hospital of Lanzhou UniversityHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineDepartment of Rehabilitation Medicine, Zhuzhou Central HospitalHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineKey Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business UniversityHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineDepartment of nephrology, Xiangtan Central HospitalHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, College of Pharmacy, Hunan University of Chinese MedicineAbstract Pulmonary hypertension (PH) was a cardiovascular disease with high morbidity and mortality. PH was a chronic disease with complicated pathogenesis and uncontrollable factors. PH was divided into five groups according to its pathogenesis and clinical manifestations. Although the treatment and diagnosis of PH has made great progress in the past ten years. However, the diagnosis and prognosis of the PAH had a great contrast, which was not conducive to the diagnosis and treatment of PH. If not treated properly, it will lead to right ventricular failure or even death. Therefore, it was necessary to explore the pathogenesis of PH. The problem we urgently need to solve was to find and develop drugs for the treatment of PH. We reviewed the PH articles in the past 10 years or so as well as systematically summarized the recent advance. We summarized the latest research on the key regulatory factors (pyroptosis, apoptosis, necroptosis, ferroptosis, and endoplasmic reticulum stress) involved in PH. To provide theoretical basis and basis for finding new therapeutic targets and research directions of PH.https://doi.org/10.1038/s41420-023-01373-6 |
| spellingShingle | Yang Sun Shasha Liu Chen Chen Songwei Yang Gang Pei Meiyu Lin Ting Wang Junpeng Long Qian Yan Jiao Yao Yuting Lin Fan Yi Lei Meng Yong Tan Qidi Ai Naihong Chen Yantao Yang The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension Cell Death Discovery |
| title | The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension |
| title_full | The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension |
| title_fullStr | The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension |
| title_full_unstemmed | The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension |
| title_short | The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension |
| title_sort | mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension |
| url | https://doi.org/10.1038/s41420-023-01373-6 |
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