Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia
One third of cases of cerebral ischemia have no clear etiology. A humoral response to the atherosclerotic plaques components beta2-glycoprotein l (beta2-gpl) and heat-shock proteins (Hsp) might be involved in the pathogenesis of stroke. This case-control study includes a complete profile of anti-bet...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2003-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500010&tlng=en |
| _version_ | 1818987397758582784 |
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| author | Henrique Luiz Staub Gary Lewis Norman Tiffany Crowther Viviane Roseli da Cunha Aline Polanczyk Jussara Maria Bohn Jefferson Gomes Fernandes Wiliam Habib Chahade Carlos Alberto von Mühlen |
| author_facet | Henrique Luiz Staub Gary Lewis Norman Tiffany Crowther Viviane Roseli da Cunha Aline Polanczyk Jussara Maria Bohn Jefferson Gomes Fernandes Wiliam Habib Chahade Carlos Alberto von Mühlen |
| author_sort | Henrique Luiz Staub |
| collection | DOAJ |
| description | One third of cases of cerebral ischemia have no clear etiology. A humoral response to the atherosclerotic plaques components beta2-glycoprotein l (beta2-gpl) and heat-shock proteins (Hsp) might be involved in the pathogenesis of stroke. This case-control study includes a complete profile of anti-beta2-gpl antibodies and testing of IgG antibodies to the 60/65 kilodaltons (kDa) Hsp in stroke patients. Ninety-three patients with acute ischemic stroke and 93 controls were evaluated for age, sex, race, hypertension, smoking, previous cardiopathy, diabetes mellitus, hypercholesterolemia and previous history of cerebral ischemia. lgG/lgM/lgA anticardiolipin (aCL) and anti-beta2-gpl antibodies, as well as lgG antibodies to human 60 kDa Hsp and to Mycobacterium bovis 65 kDa Hsp, were detected by immunoassay. Adjusted odds ratios (OR) were calculated by logistic regression. The adjusted OR for IgA anti-beta2-gpl antibodies was 4.6 (90%Cl 1.5 to 14.3; p = 0.025). The non-adjusted OR for IgG antibodies to Hsp 60 was 26.1. The adjusted OR for IgG antibodies to Hsp 65 was 3.2 (90%Cl 1.2 to 8.3; p = 0.044). The adjusted OR for lgG to any Hsp (60 or 65) was 4.8 (90%Cl 1.9 to 12.1; p = 0.006). This study demonstrates that elevated IgA anti-beta2-gpl and lgG anti-Hsp 60/65 antibodies are associated with increased risk of ischemic stroke. The association occurred independently of other risk factors. This humoral response might link autoimmunity, thrombophilia and atherosclerosis in stroke patients. |
| first_indexed | 2024-12-20T19:06:03Z |
| format | Article |
| id | doaj.art-5ed9be8af5864ea3bb9206b8434f47f4 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-20T19:06:03Z |
| publishDate | 2003-09-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-5ed9be8af5864ea3bb9206b8434f47f42022-12-21T19:29:16ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272003-09-01613B75776310.1590/S0004-282X2003000500010Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemiaHenrique Luiz Staub0Gary Lewis Norman1Tiffany Crowther2Viviane Roseli da Cunha3Aline Polanczyk4Jussara Maria Bohn5Jefferson Gomes Fernandes6Wiliam Habib Chahade7Carlos Alberto von Mühlen8Pontifícia Universidade Católica do Rio Grande do SulINOVA DiagnosticsINOVA DiagnosticsPontifícia Universidade Católica do Rio Grande do SulPontifícia Universidade Católica do Rio Grande do SulPontifícia Universidade Católica do Rio Grande do SulPontifícia Universidade Católica do Rio Grande do SulHospital do Servidor Estadual Francisco Morato de OliveiraPontifícia Universidade Católica do Rio Grande do SulOne third of cases of cerebral ischemia have no clear etiology. A humoral response to the atherosclerotic plaques components beta2-glycoprotein l (beta2-gpl) and heat-shock proteins (Hsp) might be involved in the pathogenesis of stroke. This case-control study includes a complete profile of anti-beta2-gpl antibodies and testing of IgG antibodies to the 60/65 kilodaltons (kDa) Hsp in stroke patients. Ninety-three patients with acute ischemic stroke and 93 controls were evaluated for age, sex, race, hypertension, smoking, previous cardiopathy, diabetes mellitus, hypercholesterolemia and previous history of cerebral ischemia. lgG/lgM/lgA anticardiolipin (aCL) and anti-beta2-gpl antibodies, as well as lgG antibodies to human 60 kDa Hsp and to Mycobacterium bovis 65 kDa Hsp, were detected by immunoassay. Adjusted odds ratios (OR) were calculated by logistic regression. The adjusted OR for IgA anti-beta2-gpl antibodies was 4.6 (90%Cl 1.5 to 14.3; p = 0.025). The non-adjusted OR for IgG antibodies to Hsp 60 was 26.1. The adjusted OR for IgG antibodies to Hsp 65 was 3.2 (90%Cl 1.2 to 8.3; p = 0.044). The adjusted OR for lgG to any Hsp (60 or 65) was 4.8 (90%Cl 1.9 to 12.1; p = 0.006). This study demonstrates that elevated IgA anti-beta2-gpl and lgG anti-Hsp 60/65 antibodies are associated with increased risk of ischemic stroke. The association occurred independently of other risk factors. This humoral response might link autoimmunity, thrombophilia and atherosclerosis in stroke patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500010&tlng=enanti-beta2-gpl antibodiesanti-Hsp 60/65 antibodiesacute cerebral ischemia |
| spellingShingle | Henrique Luiz Staub Gary Lewis Norman Tiffany Crowther Viviane Roseli da Cunha Aline Polanczyk Jussara Maria Bohn Jefferson Gomes Fernandes Wiliam Habib Chahade Carlos Alberto von Mühlen Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia Arquivos de Neuro-Psiquiatria anti-beta2-gpl antibodies anti-Hsp 60/65 antibodies acute cerebral ischemia |
| title | Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia |
| title_full | Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia |
| title_fullStr | Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia |
| title_full_unstemmed | Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia |
| title_short | Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia |
| title_sort | antibodies to the atherosclerotic plaque components beta2 glycoprotein i and heat shock proteins as risk factors for acute cerebral ischemia |
| topic | anti-beta2-gpl antibodies anti-Hsp 60/65 antibodies acute cerebral ischemia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500010&tlng=en |
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