Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes
AIM: To assess the correlation between choroidal thickness (CT) and the early stages of diabetic retinopathy (DR) in type 2 diabetic patients. METHODS: We divided 83 diabetic patients (51-80 years of age; 50 females) into non diabetic retinopathy group (NDR) and mild/moderate nonproliferative diabe...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-04-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2017/4/20170418.pdf |
| _version_ | 1818720258135949312 |
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| author | Zhi-Jun Shen Xiu-Fen Yang Jun Xu Chong-Yang She Wen-Wen Wei Wan-Lu Zhu Ning-Pu Liu |
| author_facet | Zhi-Jun Shen Xiu-Fen Yang Jun Xu Chong-Yang She Wen-Wen Wei Wan-Lu Zhu Ning-Pu Liu |
| author_sort | Zhi-Jun Shen |
| collection | DOAJ |
| description | AIM: To assess the correlation between choroidal thickness (CT) and the early stages of diabetic retinopathy (DR) in type 2 diabetic patients.
METHODS: We divided 83 diabetic patients (51-80 years of age; 50 females) into non diabetic retinopathy group (NDR) and mild/moderate nonproliferative diabetic retinopathy (NPDR) group, and compared them with 26 non-diabetic control subjects (51-78 years of age; 16 females). Subfoveal choroidal thickness (SFCT) and parafoveal choroidal thickness (PFCT) were measured using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). Ocular health status, disease duration, body mass index, and hemoglobin A1c (HbA1c) were recorded.
RESULTS: The mean ages of the NDR, NPDR, and control groups were 68.0±6.9y, 67.8±6.4y, and 65.1±6.3y, respectively (P=0.17). Pearson correlation of the right and left eyes for the control subjects was 0.95 and for the NDR subjects was 0.93. SFCT for the right eyes of the controls was 252.77± 41.10 μm, which was significantly thicker than that of the right eyes in NDR group (221.51±46.56 μm) and the worse eyes of the NPDR group (207.18±61.87 μm; ANOVA, P<0.01). In the diabetic patients pooled together, age was the only variable significantly associated with SFCT (multiple linear regression analysis, P=0.01).
CONCLUSION: CT decreased significantly in the NDR and mild/moderate NPDR eyes compared with the control eyes. Age is significantly associated with SFCT in the diabetic patients. Diabetic choroidopathy may be present before clinical retinopathy. |
| first_indexed | 2024-12-17T20:19:58Z |
| format | Article |
| id | doaj.art-5eda6964767b44b78af3e18789060604 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-17T20:19:58Z |
| publishDate | 2017-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-5eda6964767b44b78af3e187890606042022-12-21T21:33:58ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982017-04-0110461361810.18240/ijo.2017.04.18Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetesZhi-Jun Shen0Xiu-Fen Yang1Jun Xu2Chong-Yang She3Wen-Wen Wei4Wan-Lu Zhu5Ning-Pu Liu6Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, ChinaDepartment of Ophthalmology, the Friendship Hospital, Capital Medical University, Beijing 100050, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, ChinaAIM: To assess the correlation between choroidal thickness (CT) and the early stages of diabetic retinopathy (DR) in type 2 diabetic patients. METHODS: We divided 83 diabetic patients (51-80 years of age; 50 females) into non diabetic retinopathy group (NDR) and mild/moderate nonproliferative diabetic retinopathy (NPDR) group, and compared them with 26 non-diabetic control subjects (51-78 years of age; 16 females). Subfoveal choroidal thickness (SFCT) and parafoveal choroidal thickness (PFCT) were measured using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). Ocular health status, disease duration, body mass index, and hemoglobin A1c (HbA1c) were recorded. RESULTS: The mean ages of the NDR, NPDR, and control groups were 68.0±6.9y, 67.8±6.4y, and 65.1±6.3y, respectively (P=0.17). Pearson correlation of the right and left eyes for the control subjects was 0.95 and for the NDR subjects was 0.93. SFCT for the right eyes of the controls was 252.77± 41.10 μm, which was significantly thicker than that of the right eyes in NDR group (221.51±46.56 μm) and the worse eyes of the NPDR group (207.18±61.87 μm; ANOVA, P<0.01). In the diabetic patients pooled together, age was the only variable significantly associated with SFCT (multiple linear regression analysis, P=0.01). CONCLUSION: CT decreased significantly in the NDR and mild/moderate NPDR eyes compared with the control eyes. Age is significantly associated with SFCT in the diabetic patients. Diabetic choroidopathy may be present before clinical retinopathy.http://www.ijo.cn/en_publish/2017/4/20170418.pdf618choroidal thicknessdiabetic choroidopathydiabetic retinopathy |
| spellingShingle | Zhi-Jun Shen Xiu-Fen Yang Jun Xu Chong-Yang She Wen-Wen Wei Wan-Lu Zhu Ning-Pu Liu Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes International Journal of Ophthalmology 618 choroidal thickness diabetic choroidopathy diabetic retinopathy |
| title | Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes |
| title_full | Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes |
| title_fullStr | Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes |
| title_full_unstemmed | Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes |
| title_short | Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes |
| title_sort | association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes |
| topic | 618 choroidal thickness diabetic choroidopathy diabetic retinopathy |
| url | http://www.ijo.cn/en_publish/2017/4/20170418.pdf |
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