TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes

TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes

Abstract Tyrosine kinase 2 (TYK2), a member of the JAK family, has attracted attention as a potential therapeutic target for autoimmune diseases. However, the role of TYK2 in CD8+ T cells and autoimmune type 1 diabetes (T1D) is poorly understood. In this study, we generate Tyk2 gene knockout non-obe...

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Bibliographic Details
Main Authors: Keiichiro Mine, Seiho Nagafuchi, Satoru Akazawa, Norio Abiru, Hitoe Mori, Hironori Kurisaki, Kazuya Shimoda, Yasunobu Yoshikai, Hirokazu Takahashi, Keizo Anzai
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45573-9

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