Apolipoprotein E polymorphisms increase the risk of post-stroke depression
Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hos...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=11;spage=1790;epage=1796;aulast=Li |
| _version_ | 1818851275109826560 |
|---|---|
| author | Xue-bin Li Jie Wang An-ding Xu Jian-min Huang Lan-qing Meng Rui-ya Huang Jun-li Wang |
| author_facet | Xue-bin Li Jie Wang An-ding Xu Jian-min Huang Lan-qing Meng Rui-ya Huang Jun-li Wang |
| author_sort | Xue-bin Li |
| collection | DOAJ |
| description | Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study (including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction) to determine possible association between APOE rs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our findings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast, APOE genotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. These results suggest that the APOE rs429358 polymorphism is associated with increased risk of developing post-stroke depression, and that APOE rs429358-C allele genotypes may be detrimental to recovery of nerve function after stoke. Indeed, these findings provide clinical data for future post-stroke depression gene interventions. |
| first_indexed | 2024-12-19T07:02:26Z |
| format | Article |
| id | doaj.art-5edb22bd37c84707b3fbbead5003abbf |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-19T07:02:26Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-5edb22bd37c84707b3fbbead5003abbf2022-12-21T20:31:22ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-0111111790179610.4103/1673-5374.194748Apolipoprotein E polymorphisms increase the risk of post-stroke depressionXue-bin LiJie WangAn-ding XuJian-min HuangLan-qing MengRui-ya HuangJun-li WangRecent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study (including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction) to determine possible association between APOE rs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our findings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast, APOE genotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. These results suggest that the APOE rs429358 polymorphism is associated with increased risk of developing post-stroke depression, and that APOE rs429358-C allele genotypes may be detrimental to recovery of nerve function after stoke. Indeed, these findings provide clinical data for future post-stroke depression gene interventions.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=11;spage=1790;epage=1796;aulast=Linerve regeneration; apolipoprotein E; genetic polymorphism; post-stroke depression; risk; regional resting-state cerebral blood flow; rs429358; rs7412; cerebral infarction; neural regeneration |
| spellingShingle | Xue-bin Li Jie Wang An-ding Xu Jian-min Huang Lan-qing Meng Rui-ya Huang Jun-li Wang Apolipoprotein E polymorphisms increase the risk of post-stroke depression Neural Regeneration Research nerve regeneration; apolipoprotein E; genetic polymorphism; post-stroke depression; risk; regional resting-state cerebral blood flow; rs429358; rs7412; cerebral infarction; neural regeneration |
| title | Apolipoprotein E polymorphisms increase the risk of post-stroke depression |
| title_full | Apolipoprotein E polymorphisms increase the risk of post-stroke depression |
| title_fullStr | Apolipoprotein E polymorphisms increase the risk of post-stroke depression |
| title_full_unstemmed | Apolipoprotein E polymorphisms increase the risk of post-stroke depression |
| title_short | Apolipoprotein E polymorphisms increase the risk of post-stroke depression |
| title_sort | apolipoprotein e polymorphisms increase the risk of post stroke depression |
| topic | nerve regeneration; apolipoprotein E; genetic polymorphism; post-stroke depression; risk; regional resting-state cerebral blood flow; rs429358; rs7412; cerebral infarction; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=11;spage=1790;epage=1796;aulast=Li |
| work_keys_str_mv | AT xuebinli apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression AT jiewang apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression AT andingxu apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression AT jianminhuang apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression AT lanqingmeng apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression AT ruiyahuang apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression AT junliwang apolipoproteinepolymorphismsincreasetheriskofpoststrokedepression |