Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma
Cutaneous Melanoma (CM) is a leading cause of cancer deaths, with reports indicating a rising trend in the incidence rate of melanoma among Hispanics in certain U.S. states. The level of melanin pigmentation in the skin is suggested to render photoprotection from the DNA-damaging effects of Ultravio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-08-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/7/3/0852 |
| _version_ | 1797706252909805568 |
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| author | Amrita Dasgupta Meena Katdare |
| author_facet | Amrita Dasgupta Meena Katdare |
| author_sort | Amrita Dasgupta |
| collection | DOAJ |
| description | Cutaneous Melanoma (CM) is a leading cause of cancer deaths, with reports indicating a rising trend in the incidence rate of melanoma among Hispanics in certain U.S. states. The level of melanin pigmentation in the skin is suggested to render photoprotection from the DNA-damaging effects of Ultraviolet Radiation (UVR). UVR-induced DNA damage leads to cytogenetic defects visualized as the formation of micronuclei, multinuclei and polymorphic nuclei in cells, and a hallmark of cancer risk. The causative relationship between Sun exposure and CM is controversial, especially in Hispanics and needs further evaluation. This study was initiated with melanocytes from White, Hispanic and Black neonatal foreskins which were exposed to UVR to assess their susceptibility to UVR-induced modulation of cellular growth, cytogenetic damage, intracellular and released melanin. Our results show that White and Hispanic skin melanocytes with similar levels of constitutive melanin are susceptible to UVR-induced cytogenetic damage, whereas Black skin melanocytes are not. Our data suggest that the risk of developing UVR-induced CM in a skin type is correlated with the level of cutaneous pigmentation and its ethnic background. This study provides a benchmark for further investigation on the damaging effects of UVR as risk for CM in Hispanics. |
| first_indexed | 2024-03-12T05:49:30Z |
| format | Article |
| id | doaj.art-5edb2d268a554595989e36e0547a2653 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:49:30Z |
| publishDate | 2015-08-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5edb2d268a554595989e36e0547a26532023-09-03T05:19:32ZengMDPI AGCancers2072-66942015-08-01731586160410.3390/cancers7030852cancers7030852Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous MelanomaAmrita Dasgupta0Meena Katdare1Hampton University Skin of Color Research Institute, Hampton, VA 23668, USAHampton University Skin of Color Research Institute, Hampton, VA 23668, USACutaneous Melanoma (CM) is a leading cause of cancer deaths, with reports indicating a rising trend in the incidence rate of melanoma among Hispanics in certain U.S. states. The level of melanin pigmentation in the skin is suggested to render photoprotection from the DNA-damaging effects of Ultraviolet Radiation (UVR). UVR-induced DNA damage leads to cytogenetic defects visualized as the formation of micronuclei, multinuclei and polymorphic nuclei in cells, and a hallmark of cancer risk. The causative relationship between Sun exposure and CM is controversial, especially in Hispanics and needs further evaluation. This study was initiated with melanocytes from White, Hispanic and Black neonatal foreskins which were exposed to UVR to assess their susceptibility to UVR-induced modulation of cellular growth, cytogenetic damage, intracellular and released melanin. Our results show that White and Hispanic skin melanocytes with similar levels of constitutive melanin are susceptible to UVR-induced cytogenetic damage, whereas Black skin melanocytes are not. Our data suggest that the risk of developing UVR-induced CM in a skin type is correlated with the level of cutaneous pigmentation and its ethnic background. This study provides a benchmark for further investigation on the damaging effects of UVR as risk for CM in Hispanics.http://www.mdpi.com/2072-6694/7/3/0852cutaneous melanomaHispanicsmelanocytesultraviolet radiationDNA damagecytogenetic damagemelanin pigmentationskinethnicity |
| spellingShingle | Amrita Dasgupta Meena Katdare Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma Cancers cutaneous melanoma Hispanics melanocytes ultraviolet radiation DNA damage cytogenetic damage melanin pigmentation skin ethnicity |
| title | Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma |
| title_full | Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma |
| title_fullStr | Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma |
| title_full_unstemmed | Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma |
| title_short | Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous Melanoma |
| title_sort | ultraviolet radiation induced cytogenetic damage in white hispanic and black skin melanocytes a risk for cutaneous melanoma |
| topic | cutaneous melanoma Hispanics melanocytes ultraviolet radiation DNA damage cytogenetic damage melanin pigmentation skin ethnicity |
| url | http://www.mdpi.com/2072-6694/7/3/0852 |
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