Intestinal Enteroendocrine Cells: Present and Future Druggable Targets
Enteroendocrine cells are specialized secretory lineage cells in the small and large intestines that secrete hormones and peptides in response to luminal contents. The various hormones and peptides can act upon neighboring cells and as part of the endocrine system, circulate systemically via immune...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/10/8836 |
| _version_ | 1797599807817121792 |
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| author | Roger Atanga Varsha Singh Julie G. In |
| author_facet | Roger Atanga Varsha Singh Julie G. In |
| author_sort | Roger Atanga |
| collection | DOAJ |
| description | Enteroendocrine cells are specialized secretory lineage cells in the small and large intestines that secrete hormones and peptides in response to luminal contents. The various hormones and peptides can act upon neighboring cells and as part of the endocrine system, circulate systemically via immune cells and the enteric nervous system. Locally, enteroendocrine cells have a major role in gastrointestinal motility, nutrient sensing, and glucose metabolism. Targeting the intestinal enteroendocrine cells or mimicking hormone secretion has been an important field of study in obesity and other metabolic diseases. Studies on the importance of these cells in inflammatory and auto-immune diseases have only recently been reported. The rapid global increase in metabolic and inflammatory diseases suggests that increased understanding and novel therapies are needed. This review will focus on the association between enteroendocrine changes and metabolic and inflammatory disease progression and conclude with the future of enteroendocrine cells as potential druggable targets. |
| first_indexed | 2024-03-11T03:39:30Z |
| format | Article |
| id | doaj.art-5edbd15bedb34ae99073310286f77712 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:39:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5edbd15bedb34ae99073310286f777122023-11-18T01:42:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410883610.3390/ijms24108836Intestinal Enteroendocrine Cells: Present and Future Druggable TargetsRoger Atanga0Varsha Singh1Julie G. In2Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM 87131, USADepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM 87131, USAEnteroendocrine cells are specialized secretory lineage cells in the small and large intestines that secrete hormones and peptides in response to luminal contents. The various hormones and peptides can act upon neighboring cells and as part of the endocrine system, circulate systemically via immune cells and the enteric nervous system. Locally, enteroendocrine cells have a major role in gastrointestinal motility, nutrient sensing, and glucose metabolism. Targeting the intestinal enteroendocrine cells or mimicking hormone secretion has been an important field of study in obesity and other metabolic diseases. Studies on the importance of these cells in inflammatory and auto-immune diseases have only recently been reported. The rapid global increase in metabolic and inflammatory diseases suggests that increased understanding and novel therapies are needed. This review will focus on the association between enteroendocrine changes and metabolic and inflammatory disease progression and conclude with the future of enteroendocrine cells as potential druggable targets.https://www.mdpi.com/1422-0067/24/10/8836enteroendocrine cellsinflammatory bowel diseasemetabolic diseaseintestinal hormonestherapeutics |
| spellingShingle | Roger Atanga Varsha Singh Julie G. In Intestinal Enteroendocrine Cells: Present and Future Druggable Targets International Journal of Molecular Sciences enteroendocrine cells inflammatory bowel disease metabolic disease intestinal hormones therapeutics |
| title | Intestinal Enteroendocrine Cells: Present and Future Druggable Targets |
| title_full | Intestinal Enteroendocrine Cells: Present and Future Druggable Targets |
| title_fullStr | Intestinal Enteroendocrine Cells: Present and Future Druggable Targets |
| title_full_unstemmed | Intestinal Enteroendocrine Cells: Present and Future Druggable Targets |
| title_short | Intestinal Enteroendocrine Cells: Present and Future Druggable Targets |
| title_sort | intestinal enteroendocrine cells present and future druggable targets |
| topic | enteroendocrine cells inflammatory bowel disease metabolic disease intestinal hormones therapeutics |
| url | https://www.mdpi.com/1422-0067/24/10/8836 |
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