Self-nano-emulsifying formulation of Sonchus oleraceus Linn for improved stability: Implications for phenolics degradation under in vitro gastro-intestinal digestion

The objective of this study was to evaluate self-emulsifying drug delivery system (SNEDDS) for phenolic-extract of Sonchus oleraceus Linn (TSF-SNEDDS). The optimal prescription of the SNEDDS was as follows: isopropyl myristate (IPM) as the oil phase, Tween-20 as the emulsifier, polyethylent glycol-4...

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Bibliographic Details
Main Authors: Lei Chen, Xiujun Lin, Xiaowei Xu, Yi Chen, Kang Li, Xiaoyun Fan, Jie Pang, Hui Teng
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Journal of Functional Foods
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Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618306388
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Summary:The objective of this study was to evaluate self-emulsifying drug delivery system (SNEDDS) for phenolic-extract of Sonchus oleraceus Linn (TSF-SNEDDS). The optimal prescription of the SNEDDS was as follows: isopropyl myristate (IPM) as the oil phase, Tween-20 as the emulsifier, polyethylent glycol-400 (PEG-400) as the co-emulsifier, and the weight ratio of the three was 1:3:1 (w/w/w). The phenolic-extract loading was 11% of the prescription and it remained stable after storing at room temperature at least for 30 days without delamination. TSF-SNEDDS was found to be uniform, spherical distribution and the particle size of the emulsion was 183 ± 0.7 nm. A dynamic gastro-intestinal model was used to evaluate the behavior of TSF-SNEDDS under digestion. SNEDDS had a significant impact on stability of major phenolic compounds presented in Sonchus oleraceus Linn within the simulated gastric-intestine tract. These results indicate that SNEDDS is a promising delivery system for functional extract by increasing its stability.
ISSN:1756-4646