Advancements in stem cells treatment of skeletal muscle wasting
Muscular dystrophies (MDs) are a heterogeneous group of inherited disorders, in which progressive muscle wasting and weakness is often associated with exhaustion of muscle regeneration potential. Although physiological properties of skeletal muscle tissue are now well known, no treatments are effect...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00048/full |
| _version_ | 1818559544629919744 |
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| author | mirella emeregalli andrea efarini clementina esitzia Yvan eTorrente |
| author_facet | mirella emeregalli andrea efarini clementina esitzia Yvan eTorrente |
| author_sort | mirella emeregalli |
| collection | DOAJ |
| description | Muscular dystrophies (MDs) are a heterogeneous group of inherited disorders, in which progressive muscle wasting and weakness is often associated with exhaustion of muscle regeneration potential. Although physiological properties of skeletal muscle tissue are now well known, no treatments are effective for these diseases. Muscle regeneration was attempted by means transplantation of myogenic cells (from myoblast to embryonic stem cells) and also by interfering with the malignant processes that originate in pathological tissues, such as uncontrolled fibrosis and inflammation. Taking into account the advances in the isolation of new subpopulation of stem cells and in the creation of artificial stem cell niches, we discuss how these emerging technologies offer great promises for therapeutic approaches to muscle diseases and muscle wasting associated with aging. |
| first_indexed | 2024-12-14T00:26:56Z |
| format | Article |
| id | doaj.art-5ede27173c954b08b34738f239f719de |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T00:26:56Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-5ede27173c954b08b34738f239f719de2022-12-21T23:25:00ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-02-01510.3389/fphys.2014.0004872861Advancements in stem cells treatment of skeletal muscle wastingmirella emeregalli0andrea efarini1clementina esitzia2Yvan eTorrente3Stem Cell Laboratory Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoStem Cell Laboratory Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoStem Cell Laboratory Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoStem Cell Laboratory Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoMuscular dystrophies (MDs) are a heterogeneous group of inherited disorders, in which progressive muscle wasting and weakness is often associated with exhaustion of muscle regeneration potential. Although physiological properties of skeletal muscle tissue are now well known, no treatments are effective for these diseases. Muscle regeneration was attempted by means transplantation of myogenic cells (from myoblast to embryonic stem cells) and also by interfering with the malignant processes that originate in pathological tissues, such as uncontrolled fibrosis and inflammation. Taking into account the advances in the isolation of new subpopulation of stem cells and in the creation of artificial stem cell niches, we discuss how these emerging technologies offer great promises for therapeutic approaches to muscle diseases and muscle wasting associated with aging.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00048/fullFibrosisInflammationStem Cell Nichemuscle wastingmyogenic stem cell |
| spellingShingle | mirella emeregalli andrea efarini clementina esitzia Yvan eTorrente Advancements in stem cells treatment of skeletal muscle wasting Frontiers in Physiology Fibrosis Inflammation Stem Cell Niche muscle wasting myogenic stem cell |
| title | Advancements in stem cells treatment of skeletal muscle wasting |
| title_full | Advancements in stem cells treatment of skeletal muscle wasting |
| title_fullStr | Advancements in stem cells treatment of skeletal muscle wasting |
| title_full_unstemmed | Advancements in stem cells treatment of skeletal muscle wasting |
| title_short | Advancements in stem cells treatment of skeletal muscle wasting |
| title_sort | advancements in stem cells treatment of skeletal muscle wasting |
| topic | Fibrosis Inflammation Stem Cell Niche muscle wasting myogenic stem cell |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00048/full |
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