Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395

The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. P2Y12 has thus emerged as a therapeutic target to safely and effectively prevent secondary thrombotic events in patient...

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Bibliographic Details
Main Authors: Annachiara Mitrugno, Rachel A. Rigg, Nicole B. Laschober, Anh T. P. Ngo, Jiaqing Pang, Craig D. Williams, Joseph E. Aslan, Owen J. T. McCarty
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Platelets
Subjects:
adp
dense granules
p2y12
platelets
Online Access:http://dx.doi.org/10.1080/09537104.2017.1316482

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