A novel and practical asymmetric synthesis of eptazocine hydrobromide

A novel and practical asymmetric synthesis of eptazocine hydrobromide

In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in...

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Bibliographic Details
Main Authors: Ruipeng Li, Zhenren Liu, Liang Chen, Jing Pan, Kuaile Lin, Weicheng Zhou
Format: Article
Language:English
Published: Beilstein-Institut 2018-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkylation
asymmetric catalysis
eptazocine
Mannich cyclization
Online Access:https://doi.org/10.3762/bjoc.14.209

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