Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research
A growing interest in pharmacology has made heterocyclic chemistry as one of the emerging branches of organic chemistry. Piperazine is an excellent heterocycle that possesses a large span of pharmaceutical applications. Piperazine derived compounds have shown multiple therapeutic activities such as...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223007542 |
| _version_ | 1797615922350915584 |
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| author | Kamran Walayat Noor ul Amin Mohsin Sana Aslam Nasir Rasool Matloob Ahmad Ayesha Rafiq Sami A. Al-Hussain Magdi E.A. Zaki |
| author_facet | Kamran Walayat Noor ul Amin Mohsin Sana Aslam Nasir Rasool Matloob Ahmad Ayesha Rafiq Sami A. Al-Hussain Magdi E.A. Zaki |
| author_sort | Kamran Walayat |
| collection | DOAJ |
| description | A growing interest in pharmacology has made heterocyclic chemistry as one of the emerging branches of organic chemistry. Piperazine is an excellent heterocycle that possesses a large span of pharmaceutical applications. Piperazine derived compounds have shown multiple therapeutic activities such as antioxidant, antibacterial, analgesic, anticancer, antihypertensive, antiallergic, anti-inflammatory, antimalarial, antipsychotic, cardioprotective, antifungal, antidepressant and antiviral. FDA has approved many piperazine scaffold-based drugs for the treatment of various viral infections, therefore establishing the pharmacological importance of piperazine derivatives. Only a few reviews on antiviral activities of piperazine containing compounds are available in the literature, despite of its great medicinal significance. This review deals with piperazine derived compounds as antiviral agents covering the literature reports from 2010 to 2023. |
| first_indexed | 2024-03-11T07:33:52Z |
| format | Article |
| id | doaj.art-5ee26417cc7d4368960ead7cd91f5fac |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-11T07:33:52Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-5ee26417cc7d4368960ead7cd91f5fac2023-11-17T05:25:51ZengElsevierArabian Journal of Chemistry1878-53522023-12-011612105292Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral researchKamran Walayat0Noor ul Amin Mohsin1Sana Aslam2Nasir Rasool3Matloob Ahmad4Ayesha Rafiq5Sami A. Al-Hussain6Magdi E.A. Zaki7Department of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College Women University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, Pakistan; Corresponding authors.Department of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia; Corresponding authors.A growing interest in pharmacology has made heterocyclic chemistry as one of the emerging branches of organic chemistry. Piperazine is an excellent heterocycle that possesses a large span of pharmaceutical applications. Piperazine derived compounds have shown multiple therapeutic activities such as antioxidant, antibacterial, analgesic, anticancer, antihypertensive, antiallergic, anti-inflammatory, antimalarial, antipsychotic, cardioprotective, antifungal, antidepressant and antiviral. FDA has approved many piperazine scaffold-based drugs for the treatment of various viral infections, therefore establishing the pharmacological importance of piperazine derivatives. Only a few reviews on antiviral activities of piperazine containing compounds are available in the literature, despite of its great medicinal significance. This review deals with piperazine derived compounds as antiviral agents covering the literature reports from 2010 to 2023.http://www.sciencedirect.com/science/article/pii/S1878535223007542Antiviral piperazine derivativesAnti-SARS-CoV-2 agentsAnti-HIV agentsAnti-HCV agentsAnti-TMV agentsAnti-influenza agents |
| spellingShingle | Kamran Walayat Noor ul Amin Mohsin Sana Aslam Nasir Rasool Matloob Ahmad Ayesha Rafiq Sami A. Al-Hussain Magdi E.A. Zaki Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research Arabian Journal of Chemistry Antiviral piperazine derivatives Anti-SARS-CoV-2 agents Anti-HIV agents Anti-HCV agents Anti-TMV agents Anti-influenza agents |
| title | Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research |
| title_full | Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research |
| title_fullStr | Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research |
| title_full_unstemmed | Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research |
| title_short | Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research |
| title_sort | recent advances in the piperazine based antiviral agents a remarkable heterocycle for antiviral research |
| topic | Antiviral piperazine derivatives Anti-SARS-CoV-2 agents Anti-HIV agents Anti-HCV agents Anti-TMV agents Anti-influenza agents |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223007542 |
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