Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients

Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients

Laminin-211 deficiency leads to the most common form of congenital muscular dystrophy in childhood, MDC1A. The clinical picture is characterized by severe muscle weakness, brain abnormalities and delayed motor milestones defining MDC1A as one of the most severe forms of congenital muscular diseases....

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Bibliographic Details
Main Authors: Heike Kölbel, Denisa Hathazi, Matthew Jennings, Rita Horvath, Andreas Roos, Ulrike Schara
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neurology
Subjects:
laminin-211
laminin-α2
congenital muscular dystrophy
agrin
NudC domain-containing protein 2
muscle proteomics
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00470/full

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