Dimethyloxalylglycine Attenuates Steroid-Associated Endothelial Progenitor Cell Impairment and Osteonecrosis of the Femoral Head by Regulating the HIF-1α Signaling Pathway

Dimethyloxalylglycine Attenuates Steroid-Associated Endothelial Progenitor Cell Impairment and Osteonecrosis of the Femoral Head by Regulating the HIF-1α Signaling Pathway

Endothelial impairment and dysfunction are closely related to the pathogenesis of steroid-associated osteonecrosis of the femoral head (SONFH). Recent studies have showed that hypoxia inducible factor-1α (HIF-1α) plays a crucial role in endothelial homeostasis maintenance. Dimethyloxalylglycine (DMO...

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Bibliographic Details
Main Authors: Wenkai Shao, Zilin Li, Bo Wang, Song Gong, Ping Wang, Beite Song, Zhixiang Chen, Yong Feng
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
steroid-associated osteonecrosis of the femoral head
endothelial dysfunction
endothelial progenitor cells
HIF-1α
dimethyloxalylglycine
Online Access:https://www.mdpi.com/2227-9059/11/4/992

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