RNA Modification in Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some popula...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1695 |
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| author | Mika Nakayama Yuki Ozato Yoshiko Tsuji Yasuko Arao Chihiro Otsuka Yumiko Hamano Genzo Sumi Ken Ofusa Shizuka Uchida Andrea Vecchione Hideshi Ishii |
| author_facet | Mika Nakayama Yuki Ozato Yoshiko Tsuji Yasuko Arao Chihiro Otsuka Yumiko Hamano Genzo Sumi Ken Ofusa Shizuka Uchida Andrea Vecchione Hideshi Ishii |
| author_sort | Mika Nakayama |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches. |
| first_indexed | 2024-03-09T10:22:11Z |
| format | Article |
| id | doaj.art-5ee4a293e53143e4847be121bf7cd1f8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:22:11Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5ee4a293e53143e4847be121bf7cd1f82023-12-01T21:56:20ZengMDPI AGBiomedicines2227-90592022-07-01107169510.3390/biomedicines10071695RNA Modification in Inflammatory Bowel DiseasesMika Nakayama0Yuki Ozato1Yoshiko Tsuji2Yasuko Arao3Chihiro Otsuka4Yumiko Hamano5Genzo Sumi6Ken Ofusa7Shizuka Uchida8Andrea Vecchione9Hideshi Ishii10Department of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, Frederikskaj 10B, 2. (Building C), 2450 Copenhagen SV, DenmarkDepartment of Clinical and Molecular Medicine, University of Rome “Sapienza,” Santo Andrea Hospital, Via di Grottarossa, 1035-00189 Rome, ItalyDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanInflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches.https://www.mdpi.com/2227-9059/10/7/1695RNA modificationinflammatory bowel disease |
| spellingShingle | Mika Nakayama Yuki Ozato Yoshiko Tsuji Yasuko Arao Chihiro Otsuka Yumiko Hamano Genzo Sumi Ken Ofusa Shizuka Uchida Andrea Vecchione Hideshi Ishii RNA Modification in Inflammatory Bowel Diseases Biomedicines RNA modification inflammatory bowel disease |
| title | RNA Modification in Inflammatory Bowel Diseases |
| title_full | RNA Modification in Inflammatory Bowel Diseases |
| title_fullStr | RNA Modification in Inflammatory Bowel Diseases |
| title_full_unstemmed | RNA Modification in Inflammatory Bowel Diseases |
| title_short | RNA Modification in Inflammatory Bowel Diseases |
| title_sort | rna modification in inflammatory bowel diseases |
| topic | RNA modification inflammatory bowel disease |
| url | https://www.mdpi.com/2227-9059/10/7/1695 |
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