Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function?
Introduction: The association between dyslipidemia and cardiovascular disease in women has been proposed and many studies investigated calcium-vitamin D (CaD) supplementation and their effect on lipid concentrations. Objectives: This randomized single-blind study aimed to evaluate the effect of CaD...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2017-04-01
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| Series: | Journal of Nephropharmacology |
| Subjects: | |
| Online Access: | http://jnephropharmacology.com/PDF/npj-6-74.pdf |
| _version_ | 1828216666636419072 |
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| author | Maryam Javadian Shahla Yazdani Karimollah Hajian-Tilaki Roya Gharouei |
| author_facet | Maryam Javadian Shahla Yazdani Karimollah Hajian-Tilaki Roya Gharouei |
| author_sort | Maryam Javadian |
| collection | DOAJ |
| description | Introduction: The association between dyslipidemia and cardiovascular disease in women has been proposed and many studies investigated calcium-vitamin D (CaD) supplementation and their effect on lipid concentrations.
Objectives: This randomized single-blind study aimed to evaluate the effect of CaD supplementation on serum lipid levels of menopaused women with normal renal function.
Patients and Methods: In this study, 100 women 50-75 years old with cholesterol of 200-239 mg/dL, triglyceride (TG) of 150-199 mg/dL, low-density lipoprotein (LDL-C) of 100-159 mg/dL and vitamin D level less than 30 ng/mL and normal glomerular filtration rate (GFR) (>90 mL/min/1.73 m2) were investigated. First, body mass index (BMI) and waist circumference were calculated. The patients were given CaD supplement tablets made by Tehran Shimi Pharmaceutical Manufacturing Co. twice-daily (containing 500 mg calcium and 200 IU vitamin D) before breakfast and before lunch for 6 months. Then, blood lipid levels were collected after 3 and 6 months and were compared with initial data.
Results: One hundred women with average age of 62.76 ± 7.02 years and BMI of 27.98 ± 3.44 kg/m2 were enrolled. FBS, cholesterol, HDL-C and LDL-C of the patients significantly increased (P < 00.001) but the mean TG and LDL/HDL ratio significantly decreased (P < 00.001). Also, the difference in LDL/HDL ratio was not significant after 3 months, but it was significant after 6 months (P = 00.155 and P < 00.001, respectively).
Conclusion: Supplemental CaD significantly increased HDL-C and decreased TG and LDL/HDL ratio. Thus, it is recommended in menopaused women. |
| first_indexed | 2024-04-12T15:35:27Z |
| format | Article |
| id | doaj.art-5ee6c1a770e14dd2bf3748b39132a9a2 |
| institution | Directory Open Access Journal |
| issn | 2345-4202 |
| language | English |
| last_indexed | 2024-04-12T15:35:27Z |
| publishDate | 2017-04-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropharmacology |
| spelling | doaj.art-5ee6c1a770e14dd2bf3748b39132a9a22022-12-22T03:26:57ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropharmacology2345-42022017-04-0162747810.15171/npj.2017.08npj-20170606155901Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function?Maryam Javadian0Shahla Yazdani1Karimollah Hajian-Tilaki2Roya Gharouei3Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranInfertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Social Medicine and Health, Babol University of Medical Sciences, Babol, IranInfertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranIntroduction: The association between dyslipidemia and cardiovascular disease in women has been proposed and many studies investigated calcium-vitamin D (CaD) supplementation and their effect on lipid concentrations. Objectives: This randomized single-blind study aimed to evaluate the effect of CaD supplementation on serum lipid levels of menopaused women with normal renal function. Patients and Methods: In this study, 100 women 50-75 years old with cholesterol of 200-239 mg/dL, triglyceride (TG) of 150-199 mg/dL, low-density lipoprotein (LDL-C) of 100-159 mg/dL and vitamin D level less than 30 ng/mL and normal glomerular filtration rate (GFR) (>90 mL/min/1.73 m2) were investigated. First, body mass index (BMI) and waist circumference were calculated. The patients were given CaD supplement tablets made by Tehran Shimi Pharmaceutical Manufacturing Co. twice-daily (containing 500 mg calcium and 200 IU vitamin D) before breakfast and before lunch for 6 months. Then, blood lipid levels were collected after 3 and 6 months and were compared with initial data. Results: One hundred women with average age of 62.76 ± 7.02 years and BMI of 27.98 ± 3.44 kg/m2 were enrolled. FBS, cholesterol, HDL-C and LDL-C of the patients significantly increased (P < 00.001) but the mean TG and LDL/HDL ratio significantly decreased (P < 00.001). Also, the difference in LDL/HDL ratio was not significant after 3 months, but it was significant after 6 months (P = 00.155 and P < 00.001, respectively). Conclusion: Supplemental CaD significantly increased HDL-C and decreased TG and LDL/HDL ratio. Thus, it is recommended in menopaused women.http://jnephropharmacology.com/PDF/npj-6-74.pdfCalcium-vitamin D supplementationLipid profileMenopause |
| spellingShingle | Maryam Javadian Shahla Yazdani Karimollah Hajian-Tilaki Roya Gharouei Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function? Journal of Nephropharmacology Calcium-vitamin D supplementation Lipid profile Menopause |
| title | Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function? |
| title_full | Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function? |
| title_fullStr | Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function? |
| title_full_unstemmed | Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function? |
| title_short | Calcium-vitamin D supplementation; does it affect lipid profile of menopaused women with normal renal function? |
| title_sort | calcium vitamin d supplementation does it affect lipid profile of menopaused women with normal renal function |
| topic | Calcium-vitamin D supplementation Lipid profile Menopause |
| url | http://jnephropharmacology.com/PDF/npj-6-74.pdf |
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