A novel anti-TNF-α drug ozoralizumab rapidly distributes to inflamed joint tissues in a mouse model of collagen induced arthritis

A novel anti-TNF-α drug ozoralizumab rapidly distributes to inflamed joint tissues in a mouse model of collagen induced arthritis

Abstract In clinical studies, the next-generation anti-tumor necrosis factor-alpha (TNF-α) single domain antibody ozoralizumab showed high clinical efficacy shortly after the subcutaneous injection. To elucidate the mechanism underlying the rapid onset of the effects of ozoralizumab, we compared the...

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Bibliographic Details
Main Authors: Shohei Oyama, Kosuke Ebina, Yuki Etani, Makoto Hirao, Masanao Kyuuma, Yasuyuki Fujii, Katsuya Iwata, Bunichiro Ogawa, Tomoya Hasegawa, Sasagu Kawano, Yutaka Nakanishi, Seiji Okada, Ken Nakata
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23152-6

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